Filopodia and adhesion in cancer cell motility

Antti Arjonen, Riina Kaukonen, Johanna Ivaska (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

121 Citations (Scopus)

Abstract

Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell migration and they are transported actively to filopodia tips by an unconventional myosin, myosin-X. Integrin mediated adhesion stabilizes filopodia and promotes cell migration even though integrins are not essential for filopodia initiation. Myosin-X binds also PIP3 and this regulates its activation and localization to filopodia. Filopodia stimulate cell migration in many cell types and increased filopodia density has been described in cancer. Furthermore, several proteins implicated in filopodia formation, like fascin, are also relevant for cancer progression. To investigate this further, we performed a meta-analysis of the expression profiles of 10 filopodia-linked genes in human breast cancer. These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.
Original languageEnglish
Pages (from-to)421-430
Number of pages10
JournalCell Adhesion and Migration
Volume5
Issue number5
DOIs
Publication statusPublished - 2011
MoE publication typeA2 Review article in a scientific journal

Fingerprint

Pseudopodia
Cell Movement
Neoplasms
Myosins
Integrins
Cell Adhesion
Breast Neoplasms
Cell Surface Receptors
Genes
Cues
Meta-Analysis
Actins
Cell Membrane
Neoplasm Metastasis

Keywords

  • filopodia
  • integrins
  • migration
  • cancer

Cite this

Arjonen, Antti ; Kaukonen, Riina ; Ivaska, Johanna. / Filopodia and adhesion in cancer cell motility. In: Cell Adhesion and Migration. 2011 ; Vol. 5, No. 5. pp. 421-430.
@article{4e730088b2a04b5a9ad562bcdecf2ea9,
title = "Filopodia and adhesion in cancer cell motility",
abstract = "Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell migration and they are transported actively to filopodia tips by an unconventional myosin, myosin-X. Integrin mediated adhesion stabilizes filopodia and promotes cell migration even though integrins are not essential for filopodia initiation. Myosin-X binds also PIP3 and this regulates its activation and localization to filopodia. Filopodia stimulate cell migration in many cell types and increased filopodia density has been described in cancer. Furthermore, several proteins implicated in filopodia formation, like fascin, are also relevant for cancer progression. To investigate this further, we performed a meta-analysis of the expression profiles of 10 filopodia-linked genes in human breast cancer. These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.",
keywords = "filopodia, integrins, migration, cancer",
author = "Antti Arjonen and Riina Kaukonen and Johanna Ivaska",
year = "2011",
doi = "10.4161/cam.5.5.17723",
language = "English",
volume = "5",
pages = "421--430",
journal = "Cell Adhesion and Migration",
issn = "1933-6918",
publisher = "Landes Bioscience",
number = "5",

}

Arjonen, A, Kaukonen, R & Ivaska, J 2011, 'Filopodia and adhesion in cancer cell motility', Cell Adhesion and Migration, vol. 5, no. 5, pp. 421-430. https://doi.org/10.4161/cam.5.5.17723

Filopodia and adhesion in cancer cell motility. / Arjonen, Antti; Kaukonen, Riina; Ivaska, Johanna (Corresponding Author).

In: Cell Adhesion and Migration, Vol. 5, No. 5, 2011, p. 421-430.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Filopodia and adhesion in cancer cell motility

AU - Arjonen, Antti

AU - Kaukonen, Riina

AU - Ivaska, Johanna

PY - 2011

Y1 - 2011

N2 - Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell migration and they are transported actively to filopodia tips by an unconventional myosin, myosin-X. Integrin mediated adhesion stabilizes filopodia and promotes cell migration even though integrins are not essential for filopodia initiation. Myosin-X binds also PIP3 and this regulates its activation and localization to filopodia. Filopodia stimulate cell migration in many cell types and increased filopodia density has been described in cancer. Furthermore, several proteins implicated in filopodia formation, like fascin, are also relevant for cancer progression. To investigate this further, we performed a meta-analysis of the expression profiles of 10 filopodia-linked genes in human breast cancer. These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.

AB - Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell migration and they are transported actively to filopodia tips by an unconventional myosin, myosin-X. Integrin mediated adhesion stabilizes filopodia and promotes cell migration even though integrins are not essential for filopodia initiation. Myosin-X binds also PIP3 and this regulates its activation and localization to filopodia. Filopodia stimulate cell migration in many cell types and increased filopodia density has been described in cancer. Furthermore, several proteins implicated in filopodia formation, like fascin, are also relevant for cancer progression. To investigate this further, we performed a meta-analysis of the expression profiles of 10 filopodia-linked genes in human breast cancer. These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.

KW - filopodia

KW - integrins

KW - migration

KW - cancer

U2 - 10.4161/cam.5.5.17723

DO - 10.4161/cam.5.5.17723

M3 - Review Article

VL - 5

SP - 421

EP - 430

JO - Cell Adhesion and Migration

JF - Cell Adhesion and Migration

SN - 1933-6918

IS - 5

ER -