Formaldehyde dehydrogenase: Beyond phase I metabolism

Chad M. Thompson (Corresponding Author), Rebecca Ceder, Roland Grafström

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Abstract

Formaldehyde dehydrogenase, formally Class III alcohol dehydrogenase (ADH3), has recently been discovered to partially regulate nitrosothiol homeostasis by catalyzing the reduction of the endogenous nitrosylating agent S-nitrosoglutathione (GSNO). Several studies have implicated this enzyme, and in particular GSNO reduction, as playing an important role in conditions such as asthma, cardiovascular disease, and immune function. While ADH3 has received considerable attention in the biomedical literature where it is often referred to as GSNO reductase (GSNOR), ADH3-mediated GSNO reduction has received comparatively less attention in the environmental toxicology community. Herein, evidences for a role of ADH3 in cell signaling through thiol homeostasis is highlighted, underscoring that the enzyme functions more broadly than to metabolize formaldehyde.

Original languageEnglish
Pages (from-to)1-3
JournalToxicology Letters
Volume193
Issue number1
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fingerprint

glutathione-independent formaldehyde dehydrogenase
Metabolism
Homeostasis
S-Nitrosoglutathione
Ecotoxicology
Enzymes
Sulfhydryl Compounds
Formaldehyde
Cell signaling
Oxidoreductases
Cardiovascular Diseases
Asthma

Keywords

  • Formaldehyde
  • Formaldehyde dehydrogenase
  • Alcohol dehydrogenase 3
  • ADH3
  • GSNO
  • GSNO reductase
  • GSNOR

Cite this

Thompson, Chad M. ; Ceder, Rebecca ; Grafström, Roland. / Formaldehyde dehydrogenase : Beyond phase I metabolism. In: Toxicology Letters. 2010 ; Vol. 193, No. 1. pp. 1-3.
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Thompson, CM, Ceder, R & Grafström, R 2010, 'Formaldehyde dehydrogenase: Beyond phase I metabolism', Toxicology Letters, vol. 193, no. 1, pp. 1-3. https://doi.org/10.1016/j.toxlet.2009.11.023

Formaldehyde dehydrogenase : Beyond phase I metabolism. / Thompson, Chad M. (Corresponding Author); Ceder, Rebecca; Grafström, Roland.

In: Toxicology Letters, Vol. 193, No. 1, 2010, p. 1-3.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Formaldehyde dehydrogenase

T2 - Beyond phase I metabolism

AU - Thompson, Chad M.

AU - Ceder, Rebecca

AU - Grafström, Roland

PY - 2010

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AB - Formaldehyde dehydrogenase, formally Class III alcohol dehydrogenase (ADH3), has recently been discovered to partially regulate nitrosothiol homeostasis by catalyzing the reduction of the endogenous nitrosylating agent S-nitrosoglutathione (GSNO). Several studies have implicated this enzyme, and in particular GSNO reduction, as playing an important role in conditions such as asthma, cardiovascular disease, and immune function. While ADH3 has received considerable attention in the biomedical literature where it is often referred to as GSNO reductase (GSNOR), ADH3-mediated GSNO reduction has received comparatively less attention in the environmental toxicology community. Herein, evidences for a role of ADH3 in cell signaling through thiol homeostasis is highlighted, underscoring that the enzyme functions more broadly than to metabolize formaldehyde.

KW - Formaldehyde

KW - Formaldehyde dehydrogenase

KW - Alcohol dehydrogenase 3

KW - ADH3

KW - GSNO

KW - GSNO reductase

KW - GSNOR

U2 - 10.1016/j.toxlet.2009.11.023

DO - 10.1016/j.toxlet.2009.11.023

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SP - 1

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JF - Toxicology Letters

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