Formation of Ames mutagenicity and of the strong bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water

Peter Backlund (Corresponding Author), Leif Kronberg, Leena Tikkanen

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)

Abstract

Humic water was treated with different disinfectants and examined for mutagenicity, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), E-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (E-MX), adsorbable halogenated organics (AOX), and chloroform.
The highest mutagenic activity and the highest concentrations of MX and E-MX were noted for water disinfected with chlorine. An increased proportion of chlorine dioxide in the combined chlorine/chlorine dioxide treatment resulted in a decrease in the mutagenic activity and in the concentrations of MX, E-MX, AOX and chloroform.
Ozone treatment prior to chlorination gave a slight decrease in mutagenicity and in the concentrations of MX and E-MX. Although the amount of AOX in monochloramine treated water was comparable to that in chlorinated water chloramination produced considerably lower mutagenicity and lower concentrations of MX and E-MX. MX was responsible for 20 – 50% and E-MX for a few percent of the mutagenic activity generated by the disinfectants.
Original languageEnglish
Pages (from-to)1329-1336
JournalChemosphere
Volume17
Issue number7
DOIs
Publication statusPublished - 1988
MoE publication typeA1 Journal article-refereed

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Mutagens
Disinfection
mutagenicity
disinfection
Chlorine
chlorine
Disinfectants
Water
Chlorine compounds
chloroform
water
Chloroform
Chlorination
chlorination
Ozone
ozone
Halogenation
Acids
mutagen
halogenated compound

Cite this

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title = "Formation of Ames mutagenicity and of the strong bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water",
abstract = "Humic water was treated with different disinfectants and examined for mutagenicity, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), E-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (E-MX), adsorbable halogenated organics (AOX), and chloroform. The highest mutagenic activity and the highest concentrations of MX and E-MX were noted for water disinfected with chlorine. An increased proportion of chlorine dioxide in the combined chlorine/chlorine dioxide treatment resulted in a decrease in the mutagenic activity and in the concentrations of MX, E-MX, AOX and chloroform. Ozone treatment prior to chlorination gave a slight decrease in mutagenicity and in the concentrations of MX and E-MX. Although the amount of AOX in monochloramine treated water was comparable to that in chlorinated water chloramination produced considerably lower mutagenicity and lower concentrations of MX and E-MX. MX was responsible for 20 – 50{\%} and E-MX for a few percent of the mutagenic activity generated by the disinfectants.",
author = "Peter Backlund and Leif Kronberg and Leena Tikkanen",
year = "1988",
doi = "10.1016/0045-6535(88)90085-9",
language = "English",
volume = "17",
pages = "1329--1336",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier",
number = "7",

}

Formation of Ames mutagenicity and of the strong bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water. / Backlund, Peter (Corresponding Author); Kronberg, Leif; Tikkanen, Leena.

In: Chemosphere, Vol. 17, No. 7, 1988, p. 1329-1336.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Formation of Ames mutagenicity and of the strong bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water

AU - Backlund, Peter

AU - Kronberg, Leif

AU - Tikkanen, Leena

PY - 1988

Y1 - 1988

N2 - Humic water was treated with different disinfectants and examined for mutagenicity, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), E-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (E-MX), adsorbable halogenated organics (AOX), and chloroform. The highest mutagenic activity and the highest concentrations of MX and E-MX were noted for water disinfected with chlorine. An increased proportion of chlorine dioxide in the combined chlorine/chlorine dioxide treatment resulted in a decrease in the mutagenic activity and in the concentrations of MX, E-MX, AOX and chloroform. Ozone treatment prior to chlorination gave a slight decrease in mutagenicity and in the concentrations of MX and E-MX. Although the amount of AOX in monochloramine treated water was comparable to that in chlorinated water chloramination produced considerably lower mutagenicity and lower concentrations of MX and E-MX. MX was responsible for 20 – 50% and E-MX for a few percent of the mutagenic activity generated by the disinfectants.

AB - Humic water was treated with different disinfectants and examined for mutagenicity, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), E-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (E-MX), adsorbable halogenated organics (AOX), and chloroform. The highest mutagenic activity and the highest concentrations of MX and E-MX were noted for water disinfected with chlorine. An increased proportion of chlorine dioxide in the combined chlorine/chlorine dioxide treatment resulted in a decrease in the mutagenic activity and in the concentrations of MX, E-MX, AOX and chloroform. Ozone treatment prior to chlorination gave a slight decrease in mutagenicity and in the concentrations of MX and E-MX. Although the amount of AOX in monochloramine treated water was comparable to that in chlorinated water chloramination produced considerably lower mutagenicity and lower concentrations of MX and E-MX. MX was responsible for 20 – 50% and E-MX for a few percent of the mutagenic activity generated by the disinfectants.

U2 - 10.1016/0045-6535(88)90085-9

DO - 10.1016/0045-6535(88)90085-9

M3 - Article

VL - 17

SP - 1329

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JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

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