Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

Vivi-Ann Långvik (Corresponding Author), Osmo Hormi, Leena Tikkanen, Bjarne Holmbom

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Abstract

The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

Original languageEnglish
Pages (from-to)547 - 555
Number of pages9
JournalChemosphere
Volume22
Issue number5-6
DOIs
Publication statusPublished - 1991
MoE publication typeA1 Journal article-refereed

Fingerprint

Mutagens
Chlorination
Halogenation
phenolic compound
chlorination
mutagenicity
humus
Soil
mutagen
butenolide

Cite this

Långvik, Vivi-Ann ; Hormi, Osmo ; Tikkanen, Leena ; Holmbom, Bjarne. / Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds. In: Chemosphere. 1991 ; Vol. 22, No. 5-6. pp. 547 - 555.
@article{e54643faeade4197814a4fa05bbe51f8,
title = "Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds",
abstract = "The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.",
author = "Vivi-Ann L{\aa}ngvik and Osmo Hormi and Leena Tikkanen and Bjarne Holmbom",
note = "Project code: ELIT20231",
year = "1991",
doi = "10.1016/0045-6535(91)90066-M",
language = "English",
volume = "22",
pages = "547 -- 555",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier",
number = "5-6",

}

Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds. / Långvik, Vivi-Ann (Corresponding Author); Hormi, Osmo; Tikkanen, Leena; Holmbom, Bjarne.

In: Chemosphere, Vol. 22, No. 5-6, 1991, p. 547 - 555.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

AU - Långvik, Vivi-Ann

AU - Hormi, Osmo

AU - Tikkanen, Leena

AU - Holmbom, Bjarne

N1 - Project code: ELIT20231

PY - 1991

Y1 - 1991

N2 - The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

AB - The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

U2 - 10.1016/0045-6535(91)90066-M

DO - 10.1016/0045-6535(91)90066-M

M3 - Article

VL - 22

SP - 547

EP - 555

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 5-6

ER -