Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

Vivi-Ann Långvik (Corresponding Author), Osmo Hormi, Leena Tikkanen, Bjarne Holmbom

Research output: Contribution to journalArticle

32 Citations (Scopus)


The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

Original languageEnglish
Pages (from-to)547 - 555
Number of pages9
Issue number5-6
Publication statusPublished - 1991
MoE publication typeA1 Journal article-refereed


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