Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

Vivi-Ann Långvik; Osmo Hormi; Leena Tikkanen; Bjarne Holmbom

doi:10.1016/0045-6535(91)90066-M

Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

Vivi-Ann Långvik^*
, Osmo Hormi
, Leena Tikkanen
, Bjarne Holmbom

^*Corresponding author for this work

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

Original language	English
Pages (from-to)	547-555
Journal	Chemosphere
Volume	22
Issue number	5-6
DOIs	https://doi.org/10.1016/0045-6535(91)90066-M
Publication status	Published - 1991
MoE publication type	A1 Journal article-refereed

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title = "Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds",

abstract = "The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.",

author = "Vivi-Ann L{\aa}ngvik and Osmo Hormi and Leena Tikkanen and Bjarne Holmbom",

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AU - Långvik, Vivi-Ann

AU - Hormi, Osmo

AU - Tikkanen, Leena

AU - Holmbom, Bjarne

N1 - Project code: ELIT20231

PY - 1991

Y1 - 1991

N2 - The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

AB - The strong bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus. Chlorination at pH 2 produced more MX than chlorination at pH 7. Compounds structurally related to MX were also determined. MX was responsible for a major part of the total mutagenicity of the chlorination products.

U2 - 10.1016/0045-6535(91)90066-M

DO - 10.1016/0045-6535(91)90066-M

M3 - Article

SN - 0045-6535

VL - 22

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JO - Chemosphere

JF - Chemosphere

IS - 5-6

ER -

Formation of the mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and related compounds by chlorination of phenolic compounds

Abstract

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