Fractionation of mutagenic compounds formed during chlorination of humic water

Leif Kronberg, Bjarne Holmbom, Leena Tikkanen

Research output: Contribution to journalArticleScientificpeer-review

24 Citations (Scopus)

Abstract

Mutagenic compounds formed during chlorination of humic water were fractionated by reversed phase high performance liquid chromatography, size exclusion chromatography and thin layer chromatography, in sequence. Following each chromatographic separation the mutagenic compounds were found in one fraction predominantly. A remarkable purification of active compounds was achieved without serious losses of activity, thus enabling further purification and mass spectrometric studies of the main mutagens.

Original languageEnglish
Pages (from-to)343 - 347
Number of pages5
JournalScience of the Total Environment
Volume47
DOIs
Publication statusPublished - 1985
MoE publication typeNot Eligible

Fingerprint

Chlorination
Fractionation
chlorination
chromatography
Purification
purification
fractionation
Mutagens
Thin layer chromatography
Size exclusion chromatography
Water
High performance liquid chromatography
liquid chromatography
water
loss
mutagen

Cite this

Kronberg, Leif ; Holmbom, Bjarne ; Tikkanen, Leena. / Fractionation of mutagenic compounds formed during chlorination of humic water. In: Science of the Total Environment. 1985 ; Vol. 47. pp. 343 - 347.
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Fractionation of mutagenic compounds formed during chlorination of humic water. / Kronberg, Leif; Holmbom, Bjarne; Tikkanen, Leena.

In: Science of the Total Environment, Vol. 47, 1985, p. 343 - 347.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Fractionation of mutagenic compounds formed during chlorination of humic water

AU - Kronberg, Leif

AU - Holmbom, Bjarne

AU - Tikkanen, Leena

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AB - Mutagenic compounds formed during chlorination of humic water were fractionated by reversed phase high performance liquid chromatography, size exclusion chromatography and thin layer chromatography, in sequence. Following each chromatographic separation the mutagenic compounds were found in one fraction predominantly. A remarkable purification of active compounds was achieved without serious losses of activity, thus enabling further purification and mass spectrometric studies of the main mutagens.

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DO - 10.1016/0048-9697(85)90340-7

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