Function of ERBB4 is determined by alternative splicing

V. Veikkolainen, K. Vaparanta, K. Halkilahti, Kristiina Iljin, M. Sundvall, K. Elenius (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

61 Citations (Scopus)

Abstract

Alternative splicing is a central tool of evolution that significantly increases the size of transcriptomes and generates functional specification. Within the human ERBB receptor gene family, only ERBB4 is known to produce functionally distinct isoforms as a result of alternative splicing. While ErbB4 signaling has been demonstrated to regulate cellular processes involved in embryogenesis, carcinogenesis and cardiovascular and psychiatric diseases, relatively little is known about the contribution of the individual isoforms in the different biological contexts. Here, we review recent findings as well as provide novel data about the distribution and functions of the ERBB4 splice variants. These observations represent an example of how minor alterations in the transcripts of a single gene can result in even antagonistic cellular responses. The observations also underline the significance of understanding the unique functions of isoforms of a potential drug target gene.
Original languageEnglish
Pages (from-to)2647-2657
Number of pages11
JournalCell Cycle
Volume10
Issue number16
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Fingerprint

Alternative Splicing
Protein Isoforms
Genes
Transcriptome
Embryonic Development
Psychiatry
Carcinogenesis
Cardiovascular Diseases
Pharmaceutical Preparations

Keywords

  • Alternative splicing
  • cancer
  • EGFR
  • HER4
  • isoforms
  • non-neoplastic diseases

Cite this

Veikkolainen, V., Vaparanta, K., Halkilahti, K., Iljin, K., Sundvall, M., & Elenius, K. (2011). Function of ERBB4 is determined by alternative splicing. Cell Cycle, 10(16), 2647-2657. https://doi.org/10.4161/cc.10.16.17194
Veikkolainen, V. ; Vaparanta, K. ; Halkilahti, K. ; Iljin, Kristiina ; Sundvall, M. ; Elenius, K. / Function of ERBB4 is determined by alternative splicing. In: Cell Cycle. 2011 ; Vol. 10, No. 16. pp. 2647-2657.
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Veikkolainen, V, Vaparanta, K, Halkilahti, K, Iljin, K, Sundvall, M & Elenius, K 2011, 'Function of ERBB4 is determined by alternative splicing', Cell Cycle, vol. 10, no. 16, pp. 2647-2657. https://doi.org/10.4161/cc.10.16.17194

Function of ERBB4 is determined by alternative splicing. / Veikkolainen, V.; Vaparanta, K.; Halkilahti, K.; Iljin, Kristiina; Sundvall, M.; Elenius, K. (Corresponding Author).

In: Cell Cycle, Vol. 10, No. 16, 2011, p. 2647-2657.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Veikkolainen, V.

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AU - Halkilahti, K.

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AU - Elenius, K.

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AB - Alternative splicing is a central tool of evolution that significantly increases the size of transcriptomes and generates functional specification. Within the human ERBB receptor gene family, only ERBB4 is known to produce functionally distinct isoforms as a result of alternative splicing. While ErbB4 signaling has been demonstrated to regulate cellular processes involved in embryogenesis, carcinogenesis and cardiovascular and psychiatric diseases, relatively little is known about the contribution of the individual isoforms in the different biological contexts. Here, we review recent findings as well as provide novel data about the distribution and functions of the ERBB4 splice variants. These observations represent an example of how minor alterations in the transcripts of a single gene can result in even antagonistic cellular responses. The observations also underline the significance of understanding the unique functions of isoforms of a potential drug target gene.

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Veikkolainen V, Vaparanta K, Halkilahti K, Iljin K, Sundvall M, Elenius K. Function of ERBB4 is determined by alternative splicing. Cell Cycle. 2011;10(16):2647-2657. https://doi.org/10.4161/cc.10.16.17194