Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers

Laura von Lüders, Rita Tilmann, Kangho Lee, Cian Bartlam, Tanja Stimpel-Lindner, Tarja K. Nevanen, Kristiina Iljin, Kathrin C. Knirsch, Andreas Hirsch, Georg S. Duesberg (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)


We report on a controllable and specific functionalisation route for graphene field-effect transistors (GFETs) for the recognition of small physiologically active molecules. Key element is the noncovalent functionalisation of the graphene surface with perylene bisimide (PBI) molecules directly on the growth substrate. This Functional Layer Transfer enables the homogeneous self-assembly of PBI molecules on graphene, onto which antibodies are subsequently immobilised. The sensor surface was characterised by atomic force microscopy, Raman spectroscopy and electrical measurements, showing superior performance over conventional functionalisation after transfer. Specific sensing of small molecules was realised by monitoring the electrical property changes of functionalised GFET devices upon the application of methamphetamine and cortisol. The concentration dependent electrical response of our sensors was determined down to a concentration of 300 ng ml−1 for methamphetamine.

Original languageEnglish
Article numbere202219024
Number of pages6
JournalAngewandte Chemie: International Edition
Issue number22
Publication statusPublished - 22 May 2023
MoE publication typeA1 Journal article-refereed


  • Antibody-Antigen System
  • Biosensors
  • Functional Layer Transfer
  • Graphene
  • Noncovalent Functionalization


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