Gas-phase synthesis of l-leucine-coated micrometer-sized salbutamol sulphate and sodium chloride particles

Janne Raula, Annukka Kuivanen, Anna Lähde, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Abstract

Coating of micrometer-sized particles of salbutamol sulphate or sodium chloride with the amino acid l-leucine in the gas phase is described. A novel method to synthesize core particles and coat them with l-leucine simultaneously was carried out in an aerosol flow reactor. The coating was prepared via temperature-induced heterogeneous nucleation of l-leucine vapor on the 0.6–1.0 µm core particles, and subsequent growth of l-leucine crystals by physical vapor deposition. The core salbutamol particles were amorphous, whereas the NaCl core particles were crystalline. The l-leucine sublimation that took place at 140–195 °C depended on the identity of the core material due to (i) molecular interaction and (ii) phase mixing. The former was dominant with salbutamol/l-leucine particles and the latter was dominant with NaCl/l-leucine particles. During the vapor deposition, l-leucine formed a discontinuous coating layer of leafy-looking crystallites, with sizes from a few nanometers to hundreds of nanometers, pointing out from the core particle surface. The l-leucine deposition properties depended on the core morphology: l-leucine crystallites were distributed more evenly on salbutamol core surfaces than on salt core surfaces, where the crystallites were localized mainly on edges. The stability of coated salbutamol particles was retained during storage under humid conditions.
Original languageEnglish
Pages (from-to)289-297
JournalPowder Technology
Volume187
Issue number3
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Albuterol
Sodium chloride
Crystallites
Sodium Chloride
Leucine
Gases
Coatings
Vapor deposition
Molecular interactions
Sublimation
Physical vapor deposition
Aerosols
Amino acids
Nucleation
Vapors
Salts
Crystalline materials
Crystals
Sulfates
Temperature

Keywords

  • gas-phase coating
  • physiocal vapor deposition
  • pharmaceutical
  • L-leucine
  • salbutamol sulphate

Cite this

Raula, Janne ; Kuivanen, Annukka ; Lähde, Anna ; Kauppinen, Esko I. / Gas-phase synthesis of l-leucine-coated micrometer-sized salbutamol sulphate and sodium chloride particles. In: Powder Technology. 2008 ; Vol. 187, No. 3. pp. 289-297.
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abstract = "Coating of micrometer-sized particles of salbutamol sulphate or sodium chloride with the amino acid l-leucine in the gas phase is described. A novel method to synthesize core particles and coat them with l-leucine simultaneously was carried out in an aerosol flow reactor. The coating was prepared via temperature-induced heterogeneous nucleation of l-leucine vapor on the 0.6–1.0 µm core particles, and subsequent growth of l-leucine crystals by physical vapor deposition. The core salbutamol particles were amorphous, whereas the NaCl core particles were crystalline. The l-leucine sublimation that took place at 140–195 °C depended on the identity of the core material due to (i) molecular interaction and (ii) phase mixing. The former was dominant with salbutamol/l-leucine particles and the latter was dominant with NaCl/l-leucine particles. During the vapor deposition, l-leucine formed a discontinuous coating layer of leafy-looking crystallites, with sizes from a few nanometers to hundreds of nanometers, pointing out from the core particle surface. The l-leucine deposition properties depended on the core morphology: l-leucine crystallites were distributed more evenly on salbutamol core surfaces than on salt core surfaces, where the crystallites were localized mainly on edges. The stability of coated salbutamol particles was retained during storage under humid conditions.",
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Gas-phase synthesis of l-leucine-coated micrometer-sized salbutamol sulphate and sodium chloride particles. / Raula, Janne; Kuivanen, Annukka; Lähde, Anna; Kauppinen, Esko I. (Corresponding Author).

In: Powder Technology, Vol. 187, No. 3, 2008, p. 289-297.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Gas-phase synthesis of l-leucine-coated micrometer-sized salbutamol sulphate and sodium chloride particles

AU - Raula, Janne

AU - Kuivanen, Annukka

AU - Lähde, Anna

AU - Kauppinen, Esko I.

PY - 2008

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N2 - Coating of micrometer-sized particles of salbutamol sulphate or sodium chloride with the amino acid l-leucine in the gas phase is described. A novel method to synthesize core particles and coat them with l-leucine simultaneously was carried out in an aerosol flow reactor. The coating was prepared via temperature-induced heterogeneous nucleation of l-leucine vapor on the 0.6–1.0 µm core particles, and subsequent growth of l-leucine crystals by physical vapor deposition. The core salbutamol particles were amorphous, whereas the NaCl core particles were crystalline. The l-leucine sublimation that took place at 140–195 °C depended on the identity of the core material due to (i) molecular interaction and (ii) phase mixing. The former was dominant with salbutamol/l-leucine particles and the latter was dominant with NaCl/l-leucine particles. During the vapor deposition, l-leucine formed a discontinuous coating layer of leafy-looking crystallites, with sizes from a few nanometers to hundreds of nanometers, pointing out from the core particle surface. The l-leucine deposition properties depended on the core morphology: l-leucine crystallites were distributed more evenly on salbutamol core surfaces than on salt core surfaces, where the crystallites were localized mainly on edges. The stability of coated salbutamol particles was retained during storage under humid conditions.

AB - Coating of micrometer-sized particles of salbutamol sulphate or sodium chloride with the amino acid l-leucine in the gas phase is described. A novel method to synthesize core particles and coat them with l-leucine simultaneously was carried out in an aerosol flow reactor. The coating was prepared via temperature-induced heterogeneous nucleation of l-leucine vapor on the 0.6–1.0 µm core particles, and subsequent growth of l-leucine crystals by physical vapor deposition. The core salbutamol particles were amorphous, whereas the NaCl core particles were crystalline. The l-leucine sublimation that took place at 140–195 °C depended on the identity of the core material due to (i) molecular interaction and (ii) phase mixing. The former was dominant with salbutamol/l-leucine particles and the latter was dominant with NaCl/l-leucine particles. During the vapor deposition, l-leucine formed a discontinuous coating layer of leafy-looking crystallites, with sizes from a few nanometers to hundreds of nanometers, pointing out from the core particle surface. The l-leucine deposition properties depended on the core morphology: l-leucine crystallites were distributed more evenly on salbutamol core surfaces than on salt core surfaces, where the crystallites were localized mainly on edges. The stability of coated salbutamol particles was retained during storage under humid conditions.

KW - gas-phase coating

KW - physiocal vapor deposition

KW - pharmaceutical

KW - L-leucine

KW - salbutamol sulphate

U2 - 10.1016/j.powtec.2008.03.006

DO - 10.1016/j.powtec.2008.03.006

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