Gender-dependent progression of systemic metabolic states in early childhood

Janne Nikkilä, Marko Sysi-Aho, Andrey Ermolov, Tuulikki Seppänen-Laakso, Olli Simell, Samuel Kaski, Matej Orešič (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

45 Citations (Scopus)

Abstract

Little is known about the human intra‐individual metabolic profile changes over an extended period of time. Here, we introduce a novel concept suggesting that children even at a very young age can be categorized in terms of metabolic state as they advance in development. The hidden Markov models were used as a method for discovering the underlying progression in the metabolic state. We applied the methodology to study metabolic trajectories in children between birth and 4 years of age, based on a series of samples selected from a large birth cohort study. We found multiple previously unknown age‐ and gender‐related metabolome changes of potential medical significance. Specifically, we found that the major developmental state differences between girls and boys are attributed to sphingolipids. In addition, we demonstrated the feasibility of state‐based alignment of personal metabolic trajectories. We show that children have different development rates at the level of metabolome and thus the state‐based approach may be advantageous when applying metabolome profiling in search of markers for subtle (patho)physiological changes.
Original languageEnglish
Article number197
Number of pages7
JournalMolecular Systems Biology
Volume4
Issue number1
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

metabolome
Metabolome
Progression
childhood
Trajectories
Sphingolipids
trajectories
Dependent
gender
Hidden Markov models
Trajectory
sphingolipids
Cohort Study
metabolic studies
Parturition
Profiling
cohort studies
Period of time
Markov Model
Alignment

Keywords

  • hidden Markov models
  • lipid metabolism
  • metabolomics
  • multivariate longitudinal data
  • pediatrics

Cite this

Nikkilä, Janne ; Sysi-Aho, Marko ; Ermolov, Andrey ; Seppänen-Laakso, Tuulikki ; Simell, Olli ; Kaski, Samuel ; Orešič, Matej. / Gender-dependent progression of systemic metabolic states in early childhood. In: Molecular Systems Biology. 2008 ; Vol. 4, No. 1.
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Gender-dependent progression of systemic metabolic states in early childhood. / Nikkilä, Janne; Sysi-Aho, Marko; Ermolov, Andrey; Seppänen-Laakso, Tuulikki; Simell, Olli; Kaski, Samuel; Orešič, Matej (Corresponding Author).

In: Molecular Systems Biology, Vol. 4, No. 1, 197, 2008.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Nikkilä, Janne

AU - Sysi-Aho, Marko

AU - Ermolov, Andrey

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AU - Simell, Olli

AU - Kaski, Samuel

AU - Orešič, Matej

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