Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Johanna Schleutker (Corresponding Author), Agnes B. Baffoe-Bonnie, Elizabeth Gillanders, Tommi Kainu, Mary-Pat Jones, Diana Freas-Lutz, Carol Markey, Derek Gildea, Erica Riedesel, Julie Albertus, Kenneth D. Jr. Gibbs, Mika Matikainen, Pasi A. Koivisto, Teuvo Tammela, Joan E. Bailey-Wilson, J.M. Trent, Olli Kallioniemi

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Abstract

BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.

METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.

RESULTS: The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).

CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
Original languageEnglish
Pages (from-to)280-289
Number of pages10
JournalThe Prostate
Volume57
Issue number4
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

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Heredity
Prostatic Neoplasms
Genome
Population
DNA
Familial Prostate cancer

Keywords

  • genetic susceptibility
  • cancer predisposition
  • familiar cancer
  • homogeneous population

Cite this

Schleutker, J., Baffoe-Bonnie, A. B., Gillanders, E., Kainu, T., Jones, M-P., Freas-Lutz, D., ... Kallioniemi, O. (2003). Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. The Prostate, 57(4), 280-289. https://doi.org/10.1002/pros.10302
Schleutker, Johanna ; Baffoe-Bonnie, Agnes B. ; Gillanders, Elizabeth ; Kainu, Tommi ; Jones, Mary-Pat ; Freas-Lutz, Diana ; Markey, Carol ; Gildea, Derek ; Riedesel, Erica ; Albertus, Julie ; Gibbs, Kenneth D. Jr. ; Matikainen, Mika ; Koivisto, Pasi A. ; Tammela, Teuvo ; Bailey-Wilson, Joan E. ; Trent, J.M. ; Kallioniemi, Olli. / Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. In: The Prostate. 2003 ; Vol. 57, No. 4. pp. 280-289.
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title = "Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26",
abstract = "BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.RESULTS: The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.",
keywords = "genetic susceptibility, cancer predisposition, familiar cancer, homogeneous population",
author = "Johanna Schleutker and Baffoe-Bonnie, {Agnes B.} and Elizabeth Gillanders and Tommi Kainu and Mary-Pat Jones and Diana Freas-Lutz and Carol Markey and Derek Gildea and Erica Riedesel and Julie Albertus and Gibbs, {Kenneth D. Jr.} and Mika Matikainen and Koivisto, {Pasi A.} and Teuvo Tammela and Bailey-Wilson, {Joan E.} and J.M. Trent and Olli Kallioniemi",
year = "2003",
doi = "10.1002/pros.10302",
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journal = "The Prostate",
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Schleutker, J, Baffoe-Bonnie, AB, Gillanders, E, Kainu, T, Jones, M-P, Freas-Lutz, D, Markey, C, Gildea, D, Riedesel, E, Albertus, J, Gibbs, KDJ, Matikainen, M, Koivisto, PA, Tammela, T, Bailey-Wilson, JE, Trent, JM & Kallioniemi, O 2003, 'Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26', The Prostate, vol. 57, no. 4, pp. 280-289. https://doi.org/10.1002/pros.10302

Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. / Schleutker, Johanna (Corresponding Author); Baffoe-Bonnie, Agnes B.; Gillanders, Elizabeth; Kainu, Tommi; Jones, Mary-Pat; Freas-Lutz, Diana; Markey, Carol; Gildea, Derek; Riedesel, Erica; Albertus, Julie; Gibbs, Kenneth D. Jr.; Matikainen, Mika; Koivisto, Pasi A.; Tammela, Teuvo; Bailey-Wilson, Joan E.; Trent, J.M.; Kallioniemi, Olli.

In: The Prostate, Vol. 57, No. 4, 2003, p. 280-289.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

AU - Schleutker, Johanna

AU - Baffoe-Bonnie, Agnes B.

AU - Gillanders, Elizabeth

AU - Kainu, Tommi

AU - Jones, Mary-Pat

AU - Freas-Lutz, Diana

AU - Markey, Carol

AU - Gildea, Derek

AU - Riedesel, Erica

AU - Albertus, Julie

AU - Gibbs, Kenneth D. Jr.

AU - Matikainen, Mika

AU - Koivisto, Pasi A.

AU - Tammela, Teuvo

AU - Bailey-Wilson, Joan E.

AU - Trent, J.M.

AU - Kallioniemi, Olli

PY - 2003

Y1 - 2003

N2 - BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.RESULTS: The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

AB - BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.RESULTS: The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

KW - genetic susceptibility

KW - cancer predisposition

KW - familiar cancer

KW - homogeneous population

U2 - 10.1002/pros.10302

DO - 10.1002/pros.10302

M3 - Article

VL - 57

SP - 280

EP - 289

JO - The Prostate

JF - The Prostate

SN - 0270-4137

IS - 4

ER -