Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Johanna Schleutker (Corresponding Author), Agnes B. Baffoe-Bonnie, Elizabeth Gillanders, Tommi Kainu, Mary-Pat Jones, Diana Freas-Lutz, Carol Markey, Derek Gildea, Erica Riedesel, Julie Albertus, Kenneth D. Jr. Gibbs, Mika Matikainen, Pasi A. Koivisto, Teuvo Tammela, Joan E. Bailey-Wilson, J.M. Trent, Olli Kallioniemi

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Abstract

BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.

METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.

RESULTS: The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).

CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
Original languageEnglish
Pages (from-to)280-289
JournalThe Prostate
Volume57
Issue number4
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

Keywords

  • genetic susceptibility
  • cancer predisposition
  • familiar cancer
  • homogeneous population

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    Schleutker, J., Baffoe-Bonnie, A. B., Gillanders, E., Kainu, T., Jones, M-P., Freas-Lutz, D., Markey, C., Gildea, D., Riedesel, E., Albertus, J., Gibbs, K. D. J., Matikainen, M., Koivisto, P. A., Tammela, T., Bailey-Wilson, J. E., Trent, J. M., & Kallioniemi, O. (2003). Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. The Prostate, 57(4), 280-289. https://doi.org/10.1002/pros.10302