Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Johanna Schleutker; Agnes B. Baffoe-Bonnie; Elizabeth Gillanders; Tommi Kainu; Mary-Pat Jones; Diana Freas-Lutz; Carol Markey; Derek Gildea; Erica Riedesel; Julie Albertus; Kenneth D. Jr. Gibbs; Mika Matikainen; Pasi A. Koivisto; Teuvo Tammela; Joan E. Bailey-Wilson; Jeffrey M. Trent; Olli Kallioniemi

doi:10.1002/pros.10302

Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Johanna Schleutker^*
, Agnes B. Baffoe-Bonnie
, Elizabeth Gillanders
, Tommi Kainu
, Mary-Pat Jones
, Diana Freas-Lutz
, Carol Markey
, Derek Gildea
, Erica Riedesel
, Julie Albertus
, Kenneth D. Jr. Gibbs
, Mika Matikainen
, Pasi A. Koivisto
, Teuvo Tammela
, Joan E. Bailey-Wilson
, Jeffrey M. Trent
, Olli Kallioniemi

^*Corresponding author for this work

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

45 Citations (Scopus)

Abstract

BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.

METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.

RESULTS: The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two-point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).

CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

Original language	English
Pages (from-to)	280-289
Journal	The Prostate
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/pros.10302
Publication status	Published - 2003
MoE publication type	A1 Journal article-refereed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

genetic susceptibility
cancer predisposition
familiar cancer
homogeneous population

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10.1002/pros.10302

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Schleutker, J., Baffoe-Bonnie, A. B., Gillanders, E., Kainu, T., Jones, M.-P., Freas-Lutz, D., Markey, C., Gildea, D., Riedesel, E., Albertus, J., Gibbs, K. D. J., Matikainen, M., Koivisto, P. A., Tammela, T., Bailey-Wilson, J. E., Trent, J. M., & Kallioniemi, O. (2003). Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. The Prostate, 57(4), 280-289. https://doi.org/10.1002/pros.10302

@article{d080c9ec08f548ad97c0ac16f1d6703a,

title = "Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26",

abstract = "BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS: The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two-point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.",

keywords = "genetic susceptibility, cancer predisposition, familiar cancer, homogeneous population",

author = "Johanna Schleutker and Baffoe-Bonnie, \{Agnes B.\} and Elizabeth Gillanders and Tommi Kainu and Mary-Pat Jones and Diana Freas-Lutz and Carol Markey and Derek Gildea and Erica Riedesel and Julie Albertus and Gibbs, \{Kenneth D. Jr.\} and Mika Matikainen and Koivisto, \{Pasi A.\} and Teuvo Tammela and Bailey-Wilson, \{Joan E.\} and Trent, \{Jeffrey M.\} and Olli Kallioniemi",

year = "2003",

doi = "10.1002/pros.10302",

language = "English",

volume = "57",

pages = "280--289",

journal = "The Prostate",

issn = "0270-4137",

publisher = "Wiley",

number = "4",

}

Schleutker, J, Baffoe-Bonnie, AB, Gillanders, E, Kainu, T, Jones, M-P, Freas-Lutz, D, Markey, C, Gildea, D, Riedesel, E, Albertus, J, Gibbs, KDJ, Matikainen, M, Koivisto, PA, Tammela, T, Bailey-Wilson, JE, Trent, JM & Kallioniemi, O 2003, 'Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26', The Prostate, vol. 57, no. 4, pp. 280-289. https://doi.org/10.1002/pros.10302

TY - JOUR

T1 - Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

AU - Schleutker, Johanna

AU - Baffoe-Bonnie, Agnes B.

AU - Gillanders, Elizabeth

AU - Kainu, Tommi

AU - Jones, Mary-Pat

AU - Freas-Lutz, Diana

AU - Markey, Carol

AU - Gildea, Derek

AU - Riedesel, Erica

AU - Albertus, Julie

AU - Gibbs, Kenneth D. Jr.

AU - Matikainen, Mika

AU - Koivisto, Pasi A.

AU - Tammela, Teuvo

AU - Bailey-Wilson, Joan E.

AU - Trent, Jeffrey M.

AU - Kallioniemi, Olli

PY - 2003

Y1 - 2003

N2 - BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS: The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two-point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

AB - BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS: The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two-point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS: The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.

KW - genetic susceptibility

KW - cancer predisposition

KW - familiar cancer

KW - homogeneous population

U2 - 10.1002/pros.10302

DO - 10.1002/pros.10302

M3 - Article

SN - 0270-4137

VL - 57

SP - 280

EP - 289

JO - The Prostate

JF - The Prostate

IS - 4

ER -

Genome-wide scan for linkage in Finnish heredity prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

Abstract

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Keywords

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