Globular and fibrous proteins modified with deep eutectic solvents: Materials for drug delivery

Wanwan Qu, Riina Häkkinen, Jack Allen, Carmine D'Agostino, Andrew P. Abbott (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness. This study is the first to investigate the modification of both globular and fibrous protein, namely, zein, soy protein and gelatin, using deep eutectic solvents (DES) to form bioplastics, which may have application in drug delivery systems. The effects of DES content on the thermal and mechanical properties of the material were determined. Zein and soy are globular proteins, which both showed a significant change in the properties by the addition of DES. Both of these materials were, however, weaker and less ductile than the starch based materials previously reported in the literature. The material made from gelatin, a fibrous protein, showed variable properties depending on how long they were in contact with each other before pressing. Conductivity and NMR measurements indicate the existence of a continuous liquid phase, which are useful in the demonstrated application of transdermal drug delivery systems. It is shown that pharmaceutical DESs can be gelled with gelatin and this method is three times faster at delivering a pharmaceutical active ingredient across the skin barrier than from a corresponding solid formulation.

Original languageEnglish
Article number3583
JournalMolecules
Volume24
Issue number19
DOIs
Publication statusPublished - 4 Oct 2019
MoE publication typeA1 Journal article-refereed

Fingerprint

Scleroproteins
Gelatin
Drug delivery
Zein
eutectics
Eutectics
delivery
gelatins
Soybean Proteins
drugs
Drug Delivery Systems
proteins
Pharmaceutical Preparations
Elasticity
Starch
starches
pressing
toughness
Hot Temperature
ingredients

Keywords

  • Deep eutectic solvent
  • Drug delivery
  • Gelatin
  • Soy
  • Transdermal
  • Zein

Cite this

Qu, Wanwan ; Häkkinen, Riina ; Allen, Jack ; D'Agostino, Carmine ; Abbott, Andrew P. / Globular and fibrous proteins modified with deep eutectic solvents : Materials for drug delivery. In: Molecules. 2019 ; Vol. 24, No. 19.
@article{ada2f182241642a5a13d43da6885ef2e,
title = "Globular and fibrous proteins modified with deep eutectic solvents: Materials for drug delivery",
abstract = "Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness. This study is the first to investigate the modification of both globular and fibrous protein, namely, zein, soy protein and gelatin, using deep eutectic solvents (DES) to form bioplastics, which may have application in drug delivery systems. The effects of DES content on the thermal and mechanical properties of the material were determined. Zein and soy are globular proteins, which both showed a significant change in the properties by the addition of DES. Both of these materials were, however, weaker and less ductile than the starch based materials previously reported in the literature. The material made from gelatin, a fibrous protein, showed variable properties depending on how long they were in contact with each other before pressing. Conductivity and NMR measurements indicate the existence of a continuous liquid phase, which are useful in the demonstrated application of transdermal drug delivery systems. It is shown that pharmaceutical DESs can be gelled with gelatin and this method is three times faster at delivering a pharmaceutical active ingredient across the skin barrier than from a corresponding solid formulation.",
keywords = "Deep eutectic solvent, Drug delivery, Gelatin, Soy, Transdermal, Zein",
author = "Wanwan Qu and Riina H{\"a}kkinen and Jack Allen and Carmine D'Agostino and Abbott, {Andrew P.}",
year = "2019",
month = "10",
day = "4",
doi = "10.3390/molecules24193583",
language = "English",
volume = "24",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI",
number = "19",

}

Globular and fibrous proteins modified with deep eutectic solvents : Materials for drug delivery. / Qu, Wanwan; Häkkinen, Riina; Allen, Jack; D'Agostino, Carmine; Abbott, Andrew P. (Corresponding Author).

In: Molecules, Vol. 24, No. 19, 3583, 04.10.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Globular and fibrous proteins modified with deep eutectic solvents

T2 - Materials for drug delivery

AU - Qu, Wanwan

AU - Häkkinen, Riina

AU - Allen, Jack

AU - D'Agostino, Carmine

AU - Abbott, Andrew P.

PY - 2019/10/4

Y1 - 2019/10/4

N2 - Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness. This study is the first to investigate the modification of both globular and fibrous protein, namely, zein, soy protein and gelatin, using deep eutectic solvents (DES) to form bioplastics, which may have application in drug delivery systems. The effects of DES content on the thermal and mechanical properties of the material were determined. Zein and soy are globular proteins, which both showed a significant change in the properties by the addition of DES. Both of these materials were, however, weaker and less ductile than the starch based materials previously reported in the literature. The material made from gelatin, a fibrous protein, showed variable properties depending on how long they were in contact with each other before pressing. Conductivity and NMR measurements indicate the existence of a continuous liquid phase, which are useful in the demonstrated application of transdermal drug delivery systems. It is shown that pharmaceutical DESs can be gelled with gelatin and this method is three times faster at delivering a pharmaceutical active ingredient across the skin barrier than from a corresponding solid formulation.

AB - Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness. This study is the first to investigate the modification of both globular and fibrous protein, namely, zein, soy protein and gelatin, using deep eutectic solvents (DES) to form bioplastics, which may have application in drug delivery systems. The effects of DES content on the thermal and mechanical properties of the material were determined. Zein and soy are globular proteins, which both showed a significant change in the properties by the addition of DES. Both of these materials were, however, weaker and less ductile than the starch based materials previously reported in the literature. The material made from gelatin, a fibrous protein, showed variable properties depending on how long they were in contact with each other before pressing. Conductivity and NMR measurements indicate the existence of a continuous liquid phase, which are useful in the demonstrated application of transdermal drug delivery systems. It is shown that pharmaceutical DESs can be gelled with gelatin and this method is three times faster at delivering a pharmaceutical active ingredient across the skin barrier than from a corresponding solid formulation.

KW - Deep eutectic solvent

KW - Drug delivery

KW - Gelatin

KW - Soy

KW - Transdermal

KW - Zein

UR - http://www.scopus.com/inward/record.url?scp=85072964611&partnerID=8YFLogxK

U2 - 10.3390/molecules24193583

DO - 10.3390/molecules24193583

M3 - Article

C2 - 31590314

AN - SCOPUS:85072964611

VL - 24

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 19

M1 - 3583

ER -