Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques

Alexey P. Popov, Alexander V. Bykov, Sami Toppari, Matti Kinnunen, Alexander V. Priezzhev, Risto Myllylä

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Abstract

In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000mg/dL in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is more sensitive than OCT, as well for blood as for Intralipid measurements. In the case of TOF technique, glucose sensitivity in Intralipid is higher than in blood. We speculate that all this is associated with longer pathlengths of detected photons in TOF than in OCT, which is confirmed by comparison with Monte Carlo simulations.

Original languageEnglish
Article number6074920
Pages (from-to)1335-1342
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume18
Issue number4
DOIs
Publication statusPublished - 8 Jun 2012
MoE publication typeA1 Journal article-refereed

Keywords

  • Blood
  • glucose
  • Intralipid
  • laser pulse time-of-flight (TOF)
  • optical coherence tomography (OCT)

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