Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques

Alexey P. Popov; Alexander V. Bykov; Sami Toppari; Matti Kinnunen; Alexander V. Priezzhev; Risto Myllylä

doi:10.1109/JSTQE.2011.2175202

Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques

Alexey P. Popov^*
, Alexander V. Bykov
, Sami Toppari
, Matti Kinnunen
, Alexander V. Priezzhev
, Risto Myllylä

^*Corresponding author for this work

Not published at VTT

University of Oulu
Nokia Oyj
Moscow State University (MSU)

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000mg/dL in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is more sensitive than OCT, as well for blood as for Intralipid measurements. In the case of TOF technique, glucose sensitivity in Intralipid is higher than in blood. We speculate that all this is associated with longer pathlengths of detected photons in TOF than in OCT, which is confirmed by comparison with Monte Carlo simulations.

Original language	English
Article number	6074920
Pages (from-to)	1335-1342
Journal	IEEE Journal of Selected Topics in Quantum Electronics
Volume	18
Issue number	4
DOIs	https://doi.org/10.1109/JSTQE.2011.2175202
Publication status	Published - 8 Jun 2012
MoE publication type	A1 Journal article-refereed

Funding

Manuscript received August 31, 2011; revised October 19, 2011 and November 2, 2011; accepted November 3, 2011. Date of publication November 9, 2011; date of current version July 6, 2012. This work was supported in part by the Academy of Finland under Project 124176 and in part by Russian Fund for Basic Research under Project 08-02-91760-AΦ_a.

Keywords

Blood
glucose
Intralipid
laser pulse time-of-flight (TOF)
optical coherence tomography (OCT)

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10.1109/JSTQE.2011.2175202

Cite this

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title = "Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques",

abstract = "In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000mg/dL in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is more sensitive than OCT, as well for blood as for Intralipid measurements. In the case of TOF technique, glucose sensitivity in Intralipid is higher than in blood. We speculate that all this is associated with longer pathlengths of detected photons in TOF than in OCT, which is confirmed by comparison with Monte Carlo simulations.",

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doi = "10.1109/JSTQE.2011.2175202",

language = "English",

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Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques. / Popov, Alexey P.; Bykov, Alexander V.; Toppari, Sami et al.
In: IEEE Journal of Selected Topics in Quantum Electronics, Vol. 18, No. 4, 6074920, 08.06.2012, p. 1335-1342.

Research output: Contribution to journal › Article › Scientific › peer-review

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T1 - Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques

AU - Popov, Alexey P.

AU - Bykov, Alexander V.

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AU - Kinnunen, Matti

AU - Priezzhev, Alexander V.

AU - Myllylä, Risto

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KW - glucose

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Glucose sensing in flowing blood and intralipid by laser pulse time-of-flight and optical coherence tomography techniques

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