Gut microbiota affects lens and retinal lipid composition

Matej Oresic (Corresponding Author), Tuulikki Seppänen-Laakso, Laxman Yetukuri, F. Bäckhed, V. Hänninen

    Research output: Contribution to journalArticleScientificpeer-review

    39 Citations (Scopus)


    The gut microbiota affects host lipid metabolism and is considered an environmental factor that contributes to development of obesity. To investigate whether the gut microbiota affects the eye lipidome, we performed comprehensive lipidomic profiling of lens and retina from conventionally raised and germ-free mice. Conventionally raised mice had diminished phosphatidylcholines in the lens and elevated ethanolamine plasmalogens in the retina. Diminishment of lens phosphatidylcholines in the presence of gut microbiota suggests that the conventionally raised mice are exposed over time to more oxidative stress than germ-free mice. Consistent with this, their lifespan is also shorter. Our findings may open a new area of investigation how modulation of gut microbiota affects the eye health.
    Original languageEnglish
    Pages (from-to)604-607
    Number of pages4
    JournalExperimental Eye Research
    Issue number5
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed


    • allostasis
    • gut microbiota
    • lens
    • lipidomics
    • oxidative stress
    • phosphatidylcholine
    • plasmalogen
    • retina


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