Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Marjukka Kolehmainen (Corresponding Author), Stine M. Ulven, Jussi Paananen, Vanessa de Mello, Ursula Schwab, Carsten Carlberg, Mari Myhrstad, Jussi Pihlajamäki, Elisabeth Dunger, Eva Sjölin, Ingibjörg Gunnarsdottir, Lieselotte Cloetens, Mona Landin-Olsson, Björn Akesson, Fredrik Rosqvist, Janne Hukkanen, Karl-Heinz Herzig, Lars O. Dragsted, Markku J. Savolainen, Lea BraderKjeld Hermansen, Ulf Risérus, Inga Thorsdottir, Kaisa S. Poutanen, Matti Uusitupa, Peter Arner, Dahlman Ingrid

    Research output: Contribution to journalArticleScientificpeer-review

    39 Citations (Scopus)

    Abstract

    Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration
    Original languageEnglish
    Pages (from-to)228 - 239
    JournalThe American journal of clinical nutrition
    Volume101
    Issue number1
    DOIs
    Publication statusPublished - 2015
    MoE publication typeA1 Journal article-refereed

    Keywords

    • diet
    • metabolic syndrome
    • adipose tissue
    • genes
    • polyunsaturated fatty acids
    • transcriptome

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