Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Marjukka Kolehmainen (Corresponding Author), Stine M. Ulven, Jussi Paananen, Vanessa de Mello, Ursula Schwab, Carsten Carlberg, Mari Myhrstad, Jussi Pihlajamäki, Elisabeth Dunger, Eva Sjölin, Ingibjörg Gunnarsdottir, Lieselotte Cloetens, Mona Landin-Olsson, Björn Akesson, Fredrik Rosqvist, Janne Hukkanen, Karl-Heinz Herzig, Lars O. Dragsted, Markku J. Savolainen, Lea Brader & 7 others Kjeld Hermansen, Ulf Risérus, Inga Thorsdottir, Kaisa S. Poutanen, Matti Uusitupa, Peter Arner, Dahlman Ingrid

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration
Original languageEnglish
Pages (from-to)228 - 239
JournalThe American journal of clinical nutrition
Volume101
Issue number1
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

Fingerprint

Subcutaneous Fat
Down-Regulation
Diet
Inflammation
Gene Expression
Abdominal Subcutaneous Fat
Mediterranean Diet
Systems Biology
C-Reactive Protein
Cohort Studies
Weights and Measures
Health
Healthy Diet

Keywords

  • diet
  • metabolic syndrome
  • adipose tissue
  • genes
  • polyunsaturated fatty acids
  • transcriptome

Cite this

Kolehmainen, Marjukka ; Ulven, Stine M. ; Paananen, Jussi ; Mello, Vanessa de ; Schwab, Ursula ; Carlberg, Carsten ; Myhrstad, Mari ; Pihlajamäki, Jussi ; Dunger, Elisabeth ; Sjölin, Eva ; Gunnarsdottir, Ingibjörg ; Cloetens, Lieselotte ; Landin-Olsson, Mona ; Akesson, Björn ; Rosqvist, Fredrik ; Hukkanen, Janne ; Herzig, Karl-Heinz ; Dragsted, Lars O. ; Savolainen, Markku J. ; Brader, Lea ; Hermansen, Kjeld ; Risérus, Ulf ; Thorsdottir, Inga ; Poutanen, Kaisa S. ; Uusitupa, Matti ; Arner, Peter ; Ingrid, Dahlman. / Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. In: The American journal of clinical nutrition. 2015 ; Vol. 101, No. 1. pp. 228 - 239.
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abstract = "Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration",
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Kolehmainen, M, Ulven, SM, Paananen, J, Mello, VD, Schwab, U, Carlberg, C, Myhrstad, M, Pihlajamäki, J, Dunger, E, Sjölin, E, Gunnarsdottir, I, Cloetens, L, Landin-Olsson, M, Akesson, B, Rosqvist, F, Hukkanen, J, Herzig, K-H, Dragsted, LO, Savolainen, MJ, Brader, L, Hermansen, K, Risérus, U, Thorsdottir, I, Poutanen, KS, Uusitupa, M, Arner, P & Ingrid, D 2015, 'Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome', The American journal of clinical nutrition, vol. 101, no. 1, pp. 228 - 239. https://doi.org/10.3945/ajcn.114.092783

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. / Kolehmainen, Marjukka (Corresponding Author); Ulven, Stine M.; Paananen, Jussi; Mello, Vanessa de; Schwab, Ursula; Carlberg, Carsten; Myhrstad, Mari; Pihlajamäki, Jussi; Dunger, Elisabeth; Sjölin, Eva; Gunnarsdottir, Ingibjörg; Cloetens, Lieselotte; Landin-Olsson, Mona; Akesson, Björn; Rosqvist, Fredrik; Hukkanen, Janne; Herzig, Karl-Heinz; Dragsted, Lars O.; Savolainen, Markku J.; Brader, Lea; Hermansen, Kjeld; Risérus, Ulf; Thorsdottir, Inga; Poutanen, Kaisa S.; Uusitupa, Matti; Arner, Peter; Ingrid, Dahlman.

In: The American journal of clinical nutrition, Vol. 101, No. 1, 2015, p. 228 - 239.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Kolehmainen, Marjukka

AU - Ulven, Stine M.

AU - Paananen, Jussi

AU - Mello, Vanessa de

AU - Schwab, Ursula

AU - Carlberg, Carsten

AU - Myhrstad, Mari

AU - Pihlajamäki, Jussi

AU - Dunger, Elisabeth

AU - Sjölin, Eva

AU - Gunnarsdottir, Ingibjörg

AU - Cloetens, Lieselotte

AU - Landin-Olsson, Mona

AU - Akesson, Björn

AU - Rosqvist, Fredrik

AU - Hukkanen, Janne

AU - Herzig, Karl-Heinz

AU - Dragsted, Lars O.

AU - Savolainen, Markku J.

AU - Brader, Lea

AU - Hermansen, Kjeld

AU - Risérus, Ulf

AU - Thorsdottir, Inga

AU - Poutanen, Kaisa S.

AU - Uusitupa, Matti

AU - Arner, Peter

AU - Ingrid, Dahlman

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AB - Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration

KW - diet

KW - metabolic syndrome

KW - adipose tissue

KW - genes

KW - polyunsaturated fatty acids

KW - transcriptome

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DO - 10.3945/ajcn.114.092783

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JO - The American journal of clinical nutrition

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