TY - JOUR
T1 - Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome
AU - Kolehmainen, Marjukka
AU - Ulven, Stine M.
AU - Paananen, Jussi
AU - Mello, Vanessa de
AU - Schwab, Ursula
AU - Carlberg, Carsten
AU - Myhrstad, Mari
AU - Pihlajamäki, Jussi
AU - Dunger, Elisabeth
AU - Sjölin, Eva
AU - Gunnarsdottir, Ingibjörg
AU - Cloetens, Lieselotte
AU - Landin-Olsson, Mona
AU - Akesson, Björn
AU - Rosqvist, Fredrik
AU - Hukkanen, Janne
AU - Herzig, Karl-Heinz
AU - Dragsted, Lars O.
AU - Savolainen, Markku J.
AU - Brader, Lea
AU - Hermansen, Kjeld
AU - Risérus, Ulf
AU - Thorsdottir, Inga
AU - Poutanen, Kaisa S.
AU - Uusitupa, Matti
AU - Arner, Peter
AU - Ingrid, Dahlman
N1 - l
PY - 2015
Y1 - 2015
N2 - Background: Previously, a healthy Nordic diet (ND) has
been shown to have beneficial health effects close to
those of Mediterranean diets. Objective: The objective
was to explore whether the ND has an impact on gene
expression in abdominal subcutaneous adipose tissue (SAT)
and whether changes in gene expression are associated
with clinical and biochemical effects. Design: Obese
adults with features of the metabolic syndrome underwent
an 18- to 24-wk randomized intervention study comparing
the ND with the control diet (CD) (the SYSDIET study,
carried out within Nordic Centre of Excellence of the
Systems Biology in Controlled Dietary Interventions and
Cohort Studies). The present study included participants
from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n =
18), and Oulu (n = 18)] with a maximum weight change of
±4 kg, highly sensitive C-reactive protein concentration
AB - Background: Previously, a healthy Nordic diet (ND) has
been shown to have beneficial health effects close to
those of Mediterranean diets. Objective: The objective
was to explore whether the ND has an impact on gene
expression in abdominal subcutaneous adipose tissue (SAT)
and whether changes in gene expression are associated
with clinical and biochemical effects. Design: Obese
adults with features of the metabolic syndrome underwent
an 18- to 24-wk randomized intervention study comparing
the ND with the control diet (CD) (the SYSDIET study,
carried out within Nordic Centre of Excellence of the
Systems Biology in Controlled Dietary Interventions and
Cohort Studies). The present study included participants
from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n =
18), and Oulu (n = 18)] with a maximum weight change of
±4 kg, highly sensitive C-reactive protein concentration
KW - diet
KW - metabolic syndrome
KW - adipose tissue
KW - genes
KW - polyunsaturated fatty acids
KW - transcriptome
U2 - 10.3945/ajcn.114.092783
DO - 10.3945/ajcn.114.092783
M3 - Article
SN - 0002-9165
VL - 101
SP - 228
EP - 239
JO - The American journal of clinical nutrition
JF - The American journal of clinical nutrition
IS - 1
ER -
