Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Marjukka Kolehmainen; Stine M. Ulven; Jussi Paananen; Vanessa de Mello; Ursula Schwab; Carsten Carlberg; Mari Myhrstad; Jussi Pihlajamäki; Elisabeth Dunger; Eva Sjölin; Ingibjörg Gunnarsdottir; Lieselotte Cloetens; Mona Landin-Olsson; Björn Akesson; Fredrik Rosqvist; Janne Hukkanen; Karl-Heinz Herzig; Lars O. Dragsted; Markku J. Savolainen; Lea Brader; Kjeld Hermansen; Ulf Risérus; Inga Thorsdottir; Kaisa S. Poutanen; Matti Uusitupa; Peter Arner; Dahlman Ingrid

doi:10.3945/ajcn.114.092783

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Marjukka Kolehmainen^*
, Stine M. Ulven
, Jussi Paananen
, Vanessa de Mello
, Ursula Schwab
, Carsten Carlberg
, Mari Myhrstad
, Jussi Pihlajamäki
, Elisabeth Dunger
, Eva Sjölin
, Ingibjörg Gunnarsdottir
, Lieselotte Cloetens
, Mona Landin-Olsson
, Björn Akesson
, Fredrik Rosqvist
, Janne Hukkanen
, Karl-Heinz Herzig
, Lars O. Dragsted
, Markku J. Savolainen
, Lea Brader

Kjeld Hermansen, Ulf Risérus, Inga Thorsdottir, Kaisa S. Poutanen, Matti Uusitupa, Peter Arner, Dahlman Ingrid

^*Corresponding author for this work

Kuopio University Hospital
Aarhus University Hospital
Karolinska Institutet
Lund University
Uppsala University
University of Oulu
University of Eastern Finland

Research output: Contribution to journal › Article › Scientific › peer-review

51 Citations (Scopus)

Abstract

Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration

Original language	English
Pages (from-to)	228 - 239
Journal	American Journal of Clinical Nutrition
Volume	101
Issue number	1
DOIs	https://doi.org/10.3945/ajcn.114.092783
Publication status	Published - 2015
MoE publication type	A1 Journal article-refereed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diet
metabolic syndrome
adipose tissue
genes
polyunsaturated fatty acids
transcriptome

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10.3945/ajcn.114.092783

Cite this

Kolehmainen, M., Ulven, S. M., Paananen, J., Mello, V. D., Schwab, U., Carlberg, C., Myhrstad, M., Pihlajamäki, J., Dunger, E., Sjölin, E., Gunnarsdottir, I., Cloetens, L., Landin-Olsson, M., Akesson, B., Rosqvist, F., Hukkanen, J., Herzig, K.-H., Dragsted, L. O., Savolainen, M. J., ... Ingrid, D. (2015). Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. American Journal of Clinical Nutrition, 101(1), 228 - 239. https://doi.org/10.3945/ajcn.114.092783

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title = "Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome",

abstract = "Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration",

keywords = "diet, metabolic syndrome, adipose tissue, genes, polyunsaturated fatty acids, transcriptome",

author = "Marjukka Kolehmainen and Ulven, \{Stine M.\} and Jussi Paananen and Mello, \{Vanessa de\} and Ursula Schwab and Carsten Carlberg and Mari Myhrstad and Jussi Pihlajam{\"a}ki and Elisabeth Dunger and Eva Sj{\"o}lin and Ingibj{\"o}rg Gunnarsdottir and Lieselotte Cloetens and Mona Landin-Olsson and Bj{\"o}rn Akesson and Fredrik Rosqvist and Janne Hukkanen and Karl-Heinz Herzig and Dragsted, \{Lars O.\} and Savolainen, \{Markku J.\} and Lea Brader and Kjeld Hermansen and Ulf Ris{\'e}rus and Inga Thorsdottir and Poutanen, \{Kaisa S.\} and Matti Uusitupa and Peter Arner and Dahlman Ingrid",

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Kolehmainen, M, Ulven, SM, Paananen, J, Mello, VD, Schwab, U, Carlberg, C, Myhrstad, M, Pihlajamäki, J, Dunger, E, Sjölin, E, Gunnarsdottir, I, Cloetens, L, Landin-Olsson, M, Akesson, B, Rosqvist, F, Hukkanen, J, Herzig, K-H, Dragsted, LO, Savolainen, MJ, Brader, L, Hermansen, K, Risérus, U, Thorsdottir, I, Poutanen, KS, Uusitupa, M, Arner, P & Ingrid, D 2015, 'Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome', American Journal of Clinical Nutrition, vol. 101, no. 1, pp. 228 - 239. https://doi.org/10.3945/ajcn.114.092783

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. / Kolehmainen, Marjukka; Ulven, Stine M.; Paananen, Jussi et al.
In: American Journal of Clinical Nutrition, Vol. 101, No. 1, 2015, p. 228 - 239.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

AU - Kolehmainen, Marjukka

AU - Ulven, Stine M.

AU - Paananen, Jussi

AU - Mello, Vanessa de

AU - Schwab, Ursula

AU - Carlberg, Carsten

AU - Myhrstad, Mari

AU - Pihlajamäki, Jussi

AU - Dunger, Elisabeth

AU - Sjölin, Eva

AU - Gunnarsdottir, Ingibjörg

AU - Cloetens, Lieselotte

AU - Landin-Olsson, Mona

AU - Akesson, Björn

AU - Rosqvist, Fredrik

AU - Hukkanen, Janne

AU - Herzig, Karl-Heinz

AU - Dragsted, Lars O.

AU - Savolainen, Markku J.

AU - Brader, Lea

AU - Hermansen, Kjeld

AU - Risérus, Ulf

AU - Thorsdottir, Inga

AU - Poutanen, Kaisa S.

AU - Uusitupa, Matti

AU - Arner, Peter

AU - Ingrid, Dahlman

N1 - l

PY - 2015

Y1 - 2015

N2 - Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration

AB - Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects. Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration

KW - diet

KW - metabolic syndrome

KW - adipose tissue

KW - genes

KW - polyunsaturated fatty acids

KW - transcriptome

U2 - 10.3945/ajcn.114.092783

DO - 10.3945/ajcn.114.092783

M3 - Article

SN - 0002-9165

VL - 101

SP - 228

EP - 239

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 1

ER -

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Abstract

UN SDGs

Keywords

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