Heart rate dynamics during accentuated sympatho-vagal interaction

M. Tulppo, T. Mäkikallio, Tapio Seppänen, K. Airaksinen, H. Huikuri

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Concomitant sympathetic and vagal activation can occur in various physiological conditions, but there is limited information on heart rate (HR) behavior during the accentuated sympathovagal antagonism. Beat-to-beat HR and blood pressure were recorded during intravenous infusion of incremental doses of norepinephrine in 18 healthy male volunteers (mean age 23 ± 5 yr). HR and blood pressure spectra and two-dimensional Poincaré plots were generated from the baseline recordings and from the recordings at different doses of norepinephrine. The mean blood pressure increased (from 90 ± 7 to 120 ± 9 mmHg,P < 0.001), HR decreased (from 60 ± 9 to 48 ± 7 beats/min, P < 0.001), and the high-frequency spectral component of HR variability increased (P < 0.001) during the norepinephrine infusion as evidence of accentuated sympathovagal interaction. Abrupt aperiodic changes in sinus intervals that were not related to respiratory cycles or changes in blood pressure occurred in 14 of 18 subjects during the norepinephrine infusions. These fluctuations in sinus intervals resulted in a complex or parabola-shaped structure of the Poincaré plots of successive R-R intervals and a widening of the high-frequency spectral peak. In four subjects, the abrupt fluctuations in sinus intervals were followed by a sudden onset of fixed R-R interval dynamics with a loss of respiratory modulation of HR, resulting in a torpedo-shaped structure of the Poincaré plots. These data show that HR behavior becomes remarkably unstable during accentuated sympathovagal interaction, resembling stochastic dynamics or deterministic chaotic behavior. These features of HR dynamics can be better identified by dynamic analysis of beat-to-beat behavior of R-R intervals than by traditional analysis techniques of HR variability.
Original languageEnglish
Pages (from-to)H810-H816
JournalAmerican Journal of Physiology: Heart and Circulatory Physiology
Volume274
Issue number3
DOIs
Publication statusPublished - 1998
MoE publication typeA1 Journal article-refereed

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Heart Rate
Norepinephrine
Blood Pressure
Torpedo
Intravenous Infusions
Healthy Volunteers

Cite this

Tulppo, M. ; Mäkikallio, T. ; Seppänen, Tapio ; Airaksinen, K. ; Huikuri, H. / Heart rate dynamics during accentuated sympatho-vagal interaction. In: American Journal of Physiology: Heart and Circulatory Physiology. 1998 ; Vol. 274, No. 3. pp. H810-H816.
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abstract = "Concomitant sympathetic and vagal activation can occur in various physiological conditions, but there is limited information on heart rate (HR) behavior during the accentuated sympathovagal antagonism. Beat-to-beat HR and blood pressure were recorded during intravenous infusion of incremental doses of norepinephrine in 18 healthy male volunteers (mean age 23 ± 5 yr). HR and blood pressure spectra and two-dimensional Poincar{\'e} plots were generated from the baseline recordings and from the recordings at different doses of norepinephrine. The mean blood pressure increased (from 90 ± 7 to 120 ± 9 mmHg,P < 0.001), HR decreased (from 60 ± 9 to 48 ± 7 beats/min, P < 0.001), and the high-frequency spectral component of HR variability increased (P < 0.001) during the norepinephrine infusion as evidence of accentuated sympathovagal interaction. Abrupt aperiodic changes in sinus intervals that were not related to respiratory cycles or changes in blood pressure occurred in 14 of 18 subjects during the norepinephrine infusions. These fluctuations in sinus intervals resulted in a complex or parabola-shaped structure of the Poincar{\'e} plots of successive R-R intervals and a widening of the high-frequency spectral peak. In four subjects, the abrupt fluctuations in sinus intervals were followed by a sudden onset of fixed R-R interval dynamics with a loss of respiratory modulation of HR, resulting in a torpedo-shaped structure of the Poincar{\'e} plots. These data show that HR behavior becomes remarkably unstable during accentuated sympathovagal interaction, resembling stochastic dynamics or deterministic chaotic behavior. These features of HR dynamics can be better identified by dynamic analysis of beat-to-beat behavior of R-R intervals than by traditional analysis techniques of HR variability.",
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Heart rate dynamics during accentuated sympatho-vagal interaction. / Tulppo, M.; Mäkikallio, T.; Seppänen, Tapio; Airaksinen, K.; Huikuri, H.

In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 274, No. 3, 1998, p. H810-H816.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Heart rate dynamics during accentuated sympatho-vagal interaction

AU - Tulppo, M.

AU - Mäkikallio, T.

AU - Seppänen, Tapio

AU - Airaksinen, K.

AU - Huikuri, H.

PY - 1998

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N2 - Concomitant sympathetic and vagal activation can occur in various physiological conditions, but there is limited information on heart rate (HR) behavior during the accentuated sympathovagal antagonism. Beat-to-beat HR and blood pressure were recorded during intravenous infusion of incremental doses of norepinephrine in 18 healthy male volunteers (mean age 23 ± 5 yr). HR and blood pressure spectra and two-dimensional Poincaré plots were generated from the baseline recordings and from the recordings at different doses of norepinephrine. The mean blood pressure increased (from 90 ± 7 to 120 ± 9 mmHg,P < 0.001), HR decreased (from 60 ± 9 to 48 ± 7 beats/min, P < 0.001), and the high-frequency spectral component of HR variability increased (P < 0.001) during the norepinephrine infusion as evidence of accentuated sympathovagal interaction. Abrupt aperiodic changes in sinus intervals that were not related to respiratory cycles or changes in blood pressure occurred in 14 of 18 subjects during the norepinephrine infusions. These fluctuations in sinus intervals resulted in a complex or parabola-shaped structure of the Poincaré plots of successive R-R intervals and a widening of the high-frequency spectral peak. In four subjects, the abrupt fluctuations in sinus intervals were followed by a sudden onset of fixed R-R interval dynamics with a loss of respiratory modulation of HR, resulting in a torpedo-shaped structure of the Poincaré plots. These data show that HR behavior becomes remarkably unstable during accentuated sympathovagal interaction, resembling stochastic dynamics or deterministic chaotic behavior. These features of HR dynamics can be better identified by dynamic analysis of beat-to-beat behavior of R-R intervals than by traditional analysis techniques of HR variability.

AB - Concomitant sympathetic and vagal activation can occur in various physiological conditions, but there is limited information on heart rate (HR) behavior during the accentuated sympathovagal antagonism. Beat-to-beat HR and blood pressure were recorded during intravenous infusion of incremental doses of norepinephrine in 18 healthy male volunteers (mean age 23 ± 5 yr). HR and blood pressure spectra and two-dimensional Poincaré plots were generated from the baseline recordings and from the recordings at different doses of norepinephrine. The mean blood pressure increased (from 90 ± 7 to 120 ± 9 mmHg,P < 0.001), HR decreased (from 60 ± 9 to 48 ± 7 beats/min, P < 0.001), and the high-frequency spectral component of HR variability increased (P < 0.001) during the norepinephrine infusion as evidence of accentuated sympathovagal interaction. Abrupt aperiodic changes in sinus intervals that were not related to respiratory cycles or changes in blood pressure occurred in 14 of 18 subjects during the norepinephrine infusions. These fluctuations in sinus intervals resulted in a complex or parabola-shaped structure of the Poincaré plots of successive R-R intervals and a widening of the high-frequency spectral peak. In four subjects, the abrupt fluctuations in sinus intervals were followed by a sudden onset of fixed R-R interval dynamics with a loss of respiratory modulation of HR, resulting in a torpedo-shaped structure of the Poincaré plots. These data show that HR behavior becomes remarkably unstable during accentuated sympathovagal interaction, resembling stochastic dynamics or deterministic chaotic behavior. These features of HR dynamics can be better identified by dynamic analysis of beat-to-beat behavior of R-R intervals than by traditional analysis techniques of HR variability.

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JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

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ER -