Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up

T. Kunnas; T. Solakivi; K. Huuskonen; A. Kalela; Jaana Renko; Seppo T. Nikkari

doi:10.1016/j.ypmed.2009.04.015

Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up

T. Kunnas, T. Solakivi, K. Huuskonen, A. Kalela, Jaana Renko, Seppo T. Nikkari (Corresponding Author)

Not published at VTT

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

OBJECTIVE: To evaluate whether hematocrit (HCT) is associated with coronary heart disease (CHD) mortality in men over 55 years of age in Finland.

METHODS: Health survey data were recorded in 1980 from 670 men, aged 55 years. The causes of deaths during a 28-year follow-up were obtained from official records. Statistical comparisons were done by Cox proportional hazard regression model after dividing the men into two groups, one with HCT<50% and the other, HCT> or =50%.

RESULTS: There were altogether 412 deaths of all causes, including 140 from CHD. In men having HCT<50%, the crude CHD mortality rate per 10,000 population was 2203, while in men with HCT> or =50%, the corresponding figure was 4255. Men with HCT> or =50% were 2.4 times (95% CI 1.6-3.5) more likely to die from CHD than were men with HCT<50%. After adjusting for established coronary risk factors, the increased risk remained 1.8-fold (95 % CI, 1.1-2.7).

CONCLUSIONS: Borderline polycythemia was associated with increased CHD mortality. The cut-off value in our study was > or =50%, proposing that for men over 55 years of age such HCT levels might be an additional risk factor.

Original language	English
Pages (from-to)	45-7
Number of pages	3
Journal	Preventive Medicine
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.ypmed.2009.04.015
Publication status	Published - Aug 2009
MoE publication type	A1 Journal article-refereed

Keywords

Aged
Biomarkers/blood
Cause of Death
Coronary Disease/blood
Finland/epidemiology
Follow-Up Studies
Health Surveys
Hematocrit
Humans
Male
Middle Aged
Polycythemia/blood
Proportional Hazards Models
Prospective Studies
Risk Assessment
Survival Analysis

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10.1016/j.ypmed.2009.04.015

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title = "Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up",

abstract = "OBJECTIVE: To evaluate whether hematocrit (HCT) is associated with coronary heart disease (CHD) mortality in men over 55 years of age in Finland.METHODS: Health survey data were recorded in 1980 from 670 men, aged 55 years. The causes of deaths during a 28-year follow-up were obtained from official records. Statistical comparisons were done by Cox proportional hazard regression model after dividing the men into two groups, one with HCT<50% and the other, HCT> or =50%.RESULTS: There were altogether 412 deaths of all causes, including 140 from CHD. In men having HCT<50%, the crude CHD mortality rate per 10,000 population was 2203, while in men with HCT> or =50%, the corresponding figure was 4255. Men with HCT> or =50% were 2.4 times (95% CI 1.6-3.5) more likely to die from CHD than were men with HCT<50%. After adjusting for established coronary risk factors, the increased risk remained 1.8-fold (95 % CI, 1.1-2.7).CONCLUSIONS: Borderline polycythemia was associated with increased CHD mortality. The cut-off value in our study was > or =50%, proposing that for men over 55 years of age such HCT levels might be an additional risk factor.",

keywords = "Aged, Biomarkers/blood, Cause of Death, Coronary Disease/blood, Finland/epidemiology, Follow-Up Studies, Health Surveys, Hematocrit, Humans, Male, Middle Aged, Polycythemia/blood, Proportional Hazards Models, Prospective Studies, Risk Assessment, Survival Analysis",

author = "T. Kunnas and T. Solakivi and K. Huuskonen and A. Kalela and Jaana Renko and Nikkari, {Seppo T.}",

year = "2009",

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doi = "10.1016/j.ypmed.2009.04.015",

language = "English",

volume = "49",

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journal = "Preventive Medicine",

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T1 - Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up

AU - Kunnas, T.

AU - Solakivi, T.

AU - Huuskonen, K.

AU - Kalela, A.

AU - Renko, Jaana

AU - Nikkari, Seppo T.

PY - 2009/8

Y1 - 2009/8

N2 - OBJECTIVE: To evaluate whether hematocrit (HCT) is associated with coronary heart disease (CHD) mortality in men over 55 years of age in Finland.METHODS: Health survey data were recorded in 1980 from 670 men, aged 55 years. The causes of deaths during a 28-year follow-up were obtained from official records. Statistical comparisons were done by Cox proportional hazard regression model after dividing the men into two groups, one with HCT<50% and the other, HCT> or =50%.RESULTS: There were altogether 412 deaths of all causes, including 140 from CHD. In men having HCT<50%, the crude CHD mortality rate per 10,000 population was 2203, while in men with HCT> or =50%, the corresponding figure was 4255. Men with HCT> or =50% were 2.4 times (95% CI 1.6-3.5) more likely to die from CHD than were men with HCT<50%. After adjusting for established coronary risk factors, the increased risk remained 1.8-fold (95 % CI, 1.1-2.7).CONCLUSIONS: Borderline polycythemia was associated with increased CHD mortality. The cut-off value in our study was > or =50%, proposing that for men over 55 years of age such HCT levels might be an additional risk factor.

AB - OBJECTIVE: To evaluate whether hematocrit (HCT) is associated with coronary heart disease (CHD) mortality in men over 55 years of age in Finland.METHODS: Health survey data were recorded in 1980 from 670 men, aged 55 years. The causes of deaths during a 28-year follow-up were obtained from official records. Statistical comparisons were done by Cox proportional hazard regression model after dividing the men into two groups, one with HCT<50% and the other, HCT> or =50%.RESULTS: There were altogether 412 deaths of all causes, including 140 from CHD. In men having HCT<50%, the crude CHD mortality rate per 10,000 population was 2203, while in men with HCT> or =50%, the corresponding figure was 4255. Men with HCT> or =50% were 2.4 times (95% CI 1.6-3.5) more likely to die from CHD than were men with HCT<50%. After adjusting for established coronary risk factors, the increased risk remained 1.8-fold (95 % CI, 1.1-2.7).CONCLUSIONS: Borderline polycythemia was associated with increased CHD mortality. The cut-off value in our study was > or =50%, proposing that for men over 55 years of age such HCT levels might be an additional risk factor.

KW - Aged

KW - Biomarkers/blood

KW - Cause of Death

KW - Coronary Disease/blood

KW - Finland/epidemiology

KW - Follow-Up Studies

KW - Health Surveys

KW - Hematocrit

KW - Humans

KW - Male

KW - Middle Aged

KW - Polycythemia/blood

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Assessment

KW - Survival Analysis

U2 - 10.1016/j.ypmed.2009.04.015

DO - 10.1016/j.ypmed.2009.04.015

M3 - Article

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SN - 0091-7435

VL - 49

SP - 45

EP - 47

JO - Preventive Medicine

JF - Preventive Medicine

IS - 1

ER -

Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up

Abstract

Keywords

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