High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota

Soile Gråsten, Katri Juntunen, Jaana Mättö, Otto Mykkänen, Hani El-Nezami, Herman Adlercreutz, Kaisa Poutanen, Hannu Mykkänen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial â-glucosidase, â-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of â-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of â-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.
Original languageEnglish
Pages (from-to)454-461
JournalNutrition Research
Volume27
Issue number8
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Bread
Triticum
Microbiota
Glucosidases
Urease
Volatile Fatty Acids
Glucuronidase
Dietary Fiber
Feces
Gastrointestinal Microbiome
Secale
Sex Characteristics
Cross-Over Studies

Keywords

  • Enterolactone
  • Fecal bacterial enzymes
  • Humans
  • Short-chain fatty acids
  • Rye bread
  • Wheat bread

Cite this

Gråsten, Soile ; Juntunen, Katri ; Mättö, Jaana ; Mykkänen, Otto ; El-Nezami, Hani ; Adlercreutz, Herman ; Poutanen, Kaisa ; Mykkänen, Hannu. / High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota. In: Nutrition Research. 2007 ; Vol. 27, No. 8. pp. 454-461.
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abstract = "We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial {\^a}-glucosidase, {\^a}-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of {\^a}-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of {\^a}-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.",
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High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota. / Gråsten, Soile; Juntunen, Katri; Mättö, Jaana; Mykkänen, Otto; El-Nezami, Hani; Adlercreutz, Herman; Poutanen, Kaisa; Mykkänen, Hannu (Corresponding Author).

In: Nutrition Research, Vol. 27, No. 8, 2007, p. 454-461.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota

AU - Gråsten, Soile

AU - Juntunen, Katri

AU - Mättö, Jaana

AU - Mykkänen, Otto

AU - El-Nezami, Hani

AU - Adlercreutz, Herman

AU - Poutanen, Kaisa

AU - Mykkänen, Hannu

PY - 2007

Y1 - 2007

N2 - We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial â-glucosidase, â-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of â-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of â-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.

AB - We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial â-glucosidase, â-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of â-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of â-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.

KW - Enterolactone

KW - Fecal bacterial enzymes

KW - Humans

KW - Short-chain fatty acids

KW - Rye bread

KW - Wheat bread

U2 - 10.1016/j.nutres.2007.05.010

DO - 10.1016/j.nutres.2007.05.010

M3 - Article

VL - 27

SP - 454

EP - 461

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 8

ER -