Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 454-461 |
| Journal | Nutrition Research |
| Volume | 27 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2007 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- Enterolactone
- Fecal bacterial enzymes
- Humans
- Short-chain fatty acids
- Rye bread
- Wheat bread
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High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota. / Gråsten, Soile; Juntunen, Katri; Mättö, Jaana; Mykkänen, Otto; El-Nezami, Hani; Adlercreutz, Herman; Poutanen, Kaisa; Mykkänen, Hannu (Corresponding Author).
In: Nutrition Research, Vol. 27, No. 8, 2007, p. 454-461.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota
AU - Gråsten, Soile
AU - Juntunen, Katri
AU - Mättö, Jaana
AU - Mykkänen, Otto
AU - El-Nezami, Hani
AU - Adlercreutz, Herman
AU - Poutanen, Kaisa
AU - Mykkänen, Hannu
PY - 2007
Y1 - 2007
N2 - We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial â-glucosidase, â-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of â-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of â-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.
AB - We have reported previously that rye bread (RB) as a part of the conventional diet affects bowel function and the metabolic activity of the microbiota differently in men and women. Because a higher intake of fiber by men could explain the difference in response, in the present randomized crossover trial, we studied the effects of a RB with increased fiber content vs white wheat bread (WB) in 39 postmenopausal women aged 59 ± 6 years (mean ± SD). The women consumed RB and WB for 8 weeks in random order. The composition of fecal microbiota; activities of bacterial â-glucosidase, â-glucuronidase, and urease; and concentration of short-chain fatty acids in feces, concentration of plasma enterolactone, fecal frequency, and consistency were determined. Mean intakes of dietary fiber were 47 ± 9 and 15 ± 4 g during the RB and WB periods, respectively. Rye bread significantly increased fecal frequency and produced softer stools, and increased the concentration of plasma enterolactone and the activities of â-glucosidase and urease as compared with WB (P < .05). There were no differences in the composition of the fecal microbiota, the activity of â-glucuronidase, and the concentration of short-chain fatty acids in feces between the test bread periods. This study shows that RB in comparison to WB improves bowel function and increases the concentration of plasma enterolactone in postmenopausal women, thus improving bowel health. However, lack of other putatively positive changes observed previously in men consuming RB indicates possible sex differences in the response of colonic microbiota to dietary fiber.
KW - Enterolactone
KW - Fecal bacterial enzymes
KW - Humans
KW - Short-chain fatty acids
KW - Rye bread
KW - Wheat bread
U2 - 10.1016/j.nutres.2007.05.010
DO - 10.1016/j.nutres.2007.05.010
M3 - Article
VL - 27
SP - 454
EP - 461
JO - Nutrition Research
JF - Nutrition Research
SN - 0271-5317
IS - 8
ER -