High-resolution deep-tissue optical imaging using anti-Stokes phosphors

Alexey Popov (Corresponding author), A. V. Karmenyan, A. V. Bykov, E. V. Khaydukov, A. V. Nechaev, O. A. Bibikova, V. Ya Panchenko, V. A. Semchishen, V. N. Seminogov, A. S. Akhmanov, V. I. Sokolov, M. T. Kinnunen, V. V. Tuchin, A. V. Zvyagin

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

5 Citations (Scopus)

Abstract

We report on the high-resolution deep-tissue imaging using novel water-dispersible upconversion nanoparticles (UCNPs) β-NaYF4:Yb 3+:Tm3+. Luminescence from the UCNP embedded into tissue-mimicking phantoms at the depth of 4 mm epi-illuminated with 975-nm laser radiation was detected. Fiber-optic detection shows 2-times better resolution compared with that obtained using CCD-based imaging modality. The conversion efficiency of upconversion particles and their cytotoxicity to HeLa cells were also investigated and reported.

Original languageEnglish
Title of host publicationNovel Biophotonic Techniques and Applications II
EditorsAlex Vitkin, Arjen Amelink
PublisherInternational Society for Optics and Photonics SPIE
Volume1
ISBN (Print)978-0-81949-650-8
DOIs
Publication statusPublished - 18 Sep 2013
MoE publication typeA4 Article in a conference publication
EventEuropean Conference on Biomedical Optics, ECBO 2013 - Munich, Germany
Duration: 12 May 201316 May 2013

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number51
Volume14
ISSN1605-7422
SeriesProceedings of SPIE
Volume8801
ISSN0277-786X

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO 2013
CountryGermany
CityMunich
Period12/05/1316/05/13

Keywords

  • biophotonics
  • luminescent nanoparticles
  • optical imaging
  • tissue-mimicking phantoms
  • upconversion nanoparticles

Fingerprint Dive into the research topics of 'High-resolution deep-tissue optical imaging using anti-Stokes phosphors'. Together they form a unique fingerprint.

  • Cite this

    Popov, A., Karmenyan, A. V., Bykov, A. V., Khaydukov, E. V., Nechaev, A. V., Bibikova, O. A., Panchenko, V. Y., Semchishen, V. A., Seminogov, V. N., Akhmanov, A. S., Sokolov, V. I., Kinnunen, M. T., Tuchin, V. V., & Zvyagin, A. V. (2013). High-resolution deep-tissue optical imaging using anti-Stokes phosphors. In A. Vitkin, & A. Amelink (Eds.), Novel Biophotonic Techniques and Applications II (Vol. 1). [88010C] International Society for Optics and Photonics SPIE. Progress in Biomedical Optics and Imaging, No. 51, Vol.. 14, Proceedings of SPIE, Vol.. 8801 https://doi.org/10.1117/12.2032805