Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides

M. Wang, Jussi Hiltunen, Christina Liedert, S. Pearce, M. Charlton, Leena Hakalahti, Pentti Karioja, R. Myllylä

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10−7 RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.
Original languageEnglish
Pages (from-to)20309-20317
Number of pages8
JournalOptics Express
Volume20
Issue number18
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

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bioinstrumentation
waveguides
composite materials
sensors
polymers
inorganic coatings
refractivity
antigens
antibodies
adsorption
sensitivity
thin films
configurations
water

Cite this

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title = "Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides",
abstract = "An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10−7 RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.",
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Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides. / Wang, M.; Hiltunen, Jussi; Liedert, Christina; Pearce, S.; Charlton, M.; Hakalahti, Leena; Karioja, Pentti; Myllylä, R.

In: Optics Express, Vol. 20, No. 18, 2012, p. 20309-20317.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Wang, M.

AU - Hiltunen, Jussi

AU - Liedert, Christina

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AU - Hakalahti, Leena

AU - Karioja, Pentti

AU - Myllylä, R.

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