Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides

Meng Wang; Jussi Hiltunen; Christina Liedert; Stuart Pearce; Martin Charlton; Leena Hakalahti; Pentti Karioja; Risto Myllylä

doi:10.1364/OE.20.020309

Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides

Meng Wang, Jussi Hiltunen, Christina Liedert, Stuart Pearce, Martin Charlton, Leena Hakalahti, Pentti Karioja, Risto Myllylä

Research output: Contribution to journal › Article › Scientific › peer-review

30 Citations (Scopus)

Abstract

An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta₂O₅ thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10⁻⁷ RIU for refractive index sensing and corresponding limit of about 100 fg/mm² for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.

Original language	English
Pages (from-to)	20309-20317
Journal	Optics Express
Volume	20
Issue number	18
DOIs	https://doi.org/10.1364/OE.20.020309
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

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title = "Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides",

abstract = "An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10−7 RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.",

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AU - Wang, Meng

AU - Hiltunen, Jussi

AU - Liedert, Christina

AU - Pearce, Stuart

AU - Charlton, Martin

AU - Hakalahti, Leena

AU - Karioja, Pentti

AU - Myllylä, Risto

PY - 2012

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AB - An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10−7 RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody – antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.

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JF - Optics Express

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Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides

Abstract

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