Highly specific layers and non-label detection methods

Inger Vikholm-Lundin, Kirsi Tappura

    Research output: Contribution to conferenceConference articleScientificpeer-review

    Abstract

    We show that the oriented highly specific layer exhibits a five-fold higher response to antigen than antibody F(ab)2-fragments that are randomly adsorbed on the sensor surface. With surface plasmon resonance CRP has been detected from serum patient samples with a detection limit that is 1000-fold of that needed for detecting cardiovascular deceases. We also report on a new concept applied to develop a synthetic receptor layer that has the same response as that of the oriented antibody layer. Very high sensitivity and selectivity of the sensing layers are even more important when non-label detection methods are used. The critical aspects of the design of a non-label molecular sensor is reported.
    Original languageEnglish
    Publication statusPublished - 2009
    MoE publication typeNot Eligible
    EventInternational Conference on Trends in Bioanalytical Sciences and Biosensors, ICTBSB 2009 - Dublin, Ireland
    Duration: 26 Jan 200927 Jan 2009

    Conference

    ConferenceInternational Conference on Trends in Bioanalytical Sciences and Biosensors, ICTBSB 2009
    Abbreviated titleICTBSB
    CountryIreland
    CityDublin
    Period26/01/0927/01/09

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  • Cite this

    Vikholm-Lundin, I., & Tappura, K. (2009). Highly specific layers and non-label detection methods. Paper presented at International Conference on Trends in Bioanalytical Sciences and Biosensors, ICTBSB 2009, Dublin, Ireland.