Abstract
We show that the oriented highly specific layer exhibits
a five-fold higher response to antigen than antibody
F(ab)2-fragments that are randomly adsorbed on the sensor
surface. With surface plasmon resonance CRP has been
detected from serum patient samples with a detection
limit that is 1000-fold of that needed for detecting
cardiovascular deceases. We also report on a new concept
applied to develop a synthetic receptor layer that has
the same response as that of the oriented antibody layer.
Very high sensitivity and selectivity of the sensing
layers are even more important when non-label detection
methods are used. The critical aspects of the design of a
non-label molecular sensor is reported.
Original language | English |
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Publication status | Published - 2009 |
MoE publication type | Not Eligible |
Event | International Conference on Trends in Bioanalytical Sciences and Biosensors, ICTBSB 2009 - Dublin, Ireland Duration: 26 Jan 2009 → 27 Jan 2009 |
Conference
Conference | International Conference on Trends in Bioanalytical Sciences and Biosensors, ICTBSB 2009 |
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Abbreviated title | ICTBSB |
Country/Territory | Ireland |
City | Dublin |
Period | 26/01/09 → 27/01/09 |