Hippocampal atrophy rate using an expectation maximization classifier with a disease-specific prior

Jyrki Lötjönen, Robin Wolz, Juha Koikkalainen, Valeria Manna, Christian Ledig, Lennart Thurfjell, Roger Lundqvist, Gunhild Waldemar, Hilkka Soininen, Daniel Rueckert

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

1 Citation (Scopus)

Abstract

Hippocampal atrophy is a well-known characteristic associated with Alzheimer's disease. In this work, we propose a 4D Expectation Maximization framework for measuring the atrophy rate of the hippocampus from serial magnetic resonance images. One novelty of the framework is a disease-specific prior that regularizes the segmentation near the borders of the hippocampus. Regions where the hippocampus tends to get larger in the follow-up images than in the baseline are penalized. Using the ADNI cohort, we obtained classification accuracies of 83 % for healthy control and Alzheimer's disease patient groups and 60 % for stable and progressive MCI groups using the baseline and 12-month follow-up images.
Original languageEnglish
Title of host publicationProceedings
Subtitle of host publicationIEEE International Symposium on Biomedical Imaging, ISBI 2012
PublisherIEEE Institute of Electrical and Electronic Engineers
Pages1164-1167
ISBN (Electronic)978-1-4577-1858-8
ISBN (Print)978-1-4577-1857-1
DOIs
Publication statusPublished - 2012
MoE publication typeA4 Article in a conference publication
Event9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: 2 May 20125 May 2012
Conference number: 9

Conference

Conference9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
Abbreviated titleISBI 2012
CountrySpain
CityBarcelona
Period2/05/125/05/12

Keywords

  • Alzheimer's disease
  • atrophy rate
  • expectation maximization classifier
  • segmentation

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    Lötjönen, J., Wolz, R., Koikkalainen, J., Manna, V., Ledig, C., Thurfjell, L., Lundqvist, R., Waldemar, G., Soininen, H., & Rueckert, D. (2012). Hippocampal atrophy rate using an expectation maximization classifier with a disease-specific prior. In Proceedings: IEEE International Symposium on Biomedical Imaging, ISBI 2012 (pp. 1164-1167). IEEE Institute of Electrical and Electronic Engineers. https://doi.org/10.1109/ISBI.2012.6235767