EU demands on comprehensive assessment of human comfort, health and safety impacts are increasing. The goal of this study was to find out ways to simulate dynamics of human-machine systems and to analyse human comfort and safety as a part of virtual prototyping. The main objectives were to model human biomechanics and behaviour and tune the human model tools in order to assess and optimize the performance of human-machine system. The main research problem was to to find out correspondence between an experimental test and simulated data in order to simulate human responses for external impacts. A commercial human modelling tool and dynamics simulation software was applied. New specified kinetic human model was developed during the research project. Tested kinetic human models can be tuned to perform moderately well at a certain point of working situation.