Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

P.T. Vesanen (Corresponding Author), J.O. Nieminen, K.C.J. Zevenhoven, J. Dabek, L.T. Parkkonen, A.V. Zhdanov, Juho Luomahaara, Juha Hassel, J. Penttilä, J. Simola, A.I. Ahonen, J.P. Mäkelä, R.J. Ilmoniemi

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.
Original languageEnglish
Pages (from-to)1795-1804
Number of pages10
JournalMagnetic Resonance in Medicine
Volume69
Issue number6
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

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Magnetoencephalography
Head
Equipment and Supplies
Magnetic Fields

Keywords

  • Magnetoencephalography
  • MEG-MRI
  • superconducting quantum interference device
  • ultra-low-field MRI

Cite this

Vesanen, P. T., Nieminen, J. O., Zevenhoven, K. C. J., Dabek, J., Parkkonen, L. T., Zhdanov, A. V., ... Ilmoniemi, R. J. (2013). Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. Magnetic Resonance in Medicine, 69(6), 1795-1804. https://doi.org/10.1002/mrm.24413
Vesanen, P.T. ; Nieminen, J.O. ; Zevenhoven, K.C.J. ; Dabek, J. ; Parkkonen, L.T. ; Zhdanov, A.V. ; Luomahaara, Juho ; Hassel, Juha ; Penttilä, J. ; Simola, J. ; Ahonen, A.I. ; Mäkelä, J.P. ; Ilmoniemi, R.J. / Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. In: Magnetic Resonance in Medicine. 2013 ; Vol. 69, No. 6. pp. 1795-1804.
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abstract = "Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.",
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Vesanen, PT, Nieminen, JO, Zevenhoven, KCJ, Dabek, J, Parkkonen, LT, Zhdanov, AV, Luomahaara, J, Hassel, J, Penttilä, J, Simola, J, Ahonen, AI, Mäkelä, JP & Ilmoniemi, RJ 2013, 'Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer', Magnetic Resonance in Medicine, vol. 69, no. 6, pp. 1795-1804. https://doi.org/10.1002/mrm.24413

Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. / Vesanen, P.T. (Corresponding Author); Nieminen, J.O.; Zevenhoven, K.C.J.; Dabek, J.; Parkkonen, L.T.; Zhdanov, A.V.; Luomahaara, Juho; Hassel, Juha; Penttilä, J.; Simola, J.; Ahonen, A.I.; Mäkelä, J.P.; Ilmoniemi, R.J.

In: Magnetic Resonance in Medicine, Vol. 69, No. 6, 2013, p. 1795-1804.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

AU - Vesanen, P.T.

AU - Nieminen, J.O.

AU - Zevenhoven, K.C.J.

AU - Dabek, J.

AU - Parkkonen, L.T.

AU - Zhdanov, A.V.

AU - Luomahaara, Juho

AU - Hassel, Juha

AU - Penttilä, J.

AU - Simola, J.

AU - Ahonen, A.I.

AU - Mäkelä, J.P.

AU - Ilmoniemi, R.J.

PY - 2013

Y1 - 2013

N2 - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

AB - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

KW - Magnetoencephalography

KW - MEG-MRI

KW - superconducting quantum interference device

KW - ultra-low-field MRI

U2 - 10.1002/mrm.24413

DO - 10.1002/mrm.24413

M3 - Article

VL - 69

SP - 1795

EP - 1804

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 6

ER -