Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

Panu T. Vesanen; Jaakko O. Nieminen; Koos C.J. Zevenhoven; Juhani Dabek; Lauri T. Parkkonen; Andrei V. Zhdanov; Juho Luomahaara; Juha Hassel; Jari Penttilä; Juha Simola; Antti I. Ahonen; Jyrki P. Mäkelä; Risto J. Ilmoniemi

doi:10.1002/mrm.24413

Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

Panu T. Vesanen (Corresponding Author), Jaakko O. Nieminen, Koos C.J. Zevenhoven, Juhani Dabek, Lauri T. Parkkonen, Andrei V. Zhdanov, Juho Luomahaara, Juha Hassel, Jari Penttilä, Juha Simola, Antti I. Ahonen, Jyrki P. Mäkelä, Risto J. Ilmoniemi

Research output: Contribution to journal › Article › Scientific › peer-review

93 Citations (Scopus)

Abstract

Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

Original language	English
Pages (from-to)	1795-1804
Journal	Magnetic Resonance in Medicine
Volume	69
Issue number	6
DOIs	https://doi.org/10.1002/mrm.24413
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Keywords

Magnetoencephalography
MEG-MRI
superconducting quantum interference device
ultra-low-field MRI

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10.1002/mrm.24413

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Vesanen, P. T., Nieminen, J. O., Zevenhoven, K. C. J., Dabek, J., Parkkonen, L. T., Zhdanov, A. V., Luomahaara, J., Hassel, J., Penttilä, J., Simola, J., Ahonen, A. I., Mäkelä, J. P., & Ilmoniemi, R. J. (2013). Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. Magnetic Resonance in Medicine, 69(6), 1795-1804. https://doi.org/10.1002/mrm.24413

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title = "Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer",

abstract = "Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.",

keywords = "Magnetoencephalography, MEG-MRI, superconducting quantum interference device, ultra-low-field MRI",

author = "Vesanen, {Panu T.} and Nieminen, {Jaakko O.} and Zevenhoven, {Koos C.J.} and Juhani Dabek and Parkkonen, {Lauri T.} and Zhdanov, {Andrei V.} and Juho Luomahaara and Juha Hassel and Jari Penttil{\"a} and Juha Simola and Ahonen, {Antti I.} and M{\"a}kel{\"a}, {Jyrki P.} and Ilmoniemi, {Risto J.}",

year = "2013",

doi = "10.1002/mrm.24413",

language = "English",

volume = "69",

pages = "1795--1804",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "Wiley",

number = "6",

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Vesanen, PT, Nieminen, JO, Zevenhoven, KCJ, Dabek, J, Parkkonen, LT, Zhdanov, AV, Luomahaara, J, Hassel, J, Penttilä, J, Simola, J, Ahonen, AI, Mäkelä, JP & Ilmoniemi, RJ 2013, 'Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer', Magnetic Resonance in Medicine, vol. 69, no. 6, pp. 1795-1804. https://doi.org/10.1002/mrm.24413

TY - JOUR

T1 - Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

AU - Vesanen, Panu T.

AU - Nieminen, Jaakko O.

AU - Zevenhoven, Koos C.J.

AU - Dabek, Juhani

AU - Parkkonen, Lauri T.

AU - Zhdanov, Andrei V.

AU - Luomahaara, Juho

AU - Hassel, Juha

AU - Penttilä, Jari

AU - Simola, Juha

AU - Ahonen, Antti I.

AU - Mäkelä, Jyrki P.

AU - Ilmoniemi, Risto J.

PY - 2013

Y1 - 2013

N2 - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

AB - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

KW - Magnetoencephalography

KW - MEG-MRI

KW - superconducting quantum interference device

KW - ultra-low-field MRI

U2 - 10.1002/mrm.24413

DO - 10.1002/mrm.24413

M3 - Article

SN - 0740-3194

VL - 69

SP - 1795

EP - 1804

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 6

ER -

Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

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Keywords

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