Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

P.T. Vesanen (Corresponding Author), J.O. Nieminen, K.C.J. Zevenhoven, J. Dabek, L.T. Parkkonen, A.V. Zhdanov, Juho Luomahaara, Juha Hassel, J. Penttilä, J. Simola, A.I. Ahonen, J.P. Mäkelä, R.J. Ilmoniemi

    Research output: Contribution to journalArticleScientificpeer-review

    77 Citations (Scopus)

    Abstract

    Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.
    Original languageEnglish
    Pages (from-to)1795-1804
    Number of pages10
    JournalMagnetic Resonance in Medicine
    Volume69
    Issue number6
    DOIs
    Publication statusPublished - 2013
    MoE publication typeA1 Journal article-refereed

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    Magnetoencephalography
    Head
    Equipment and Supplies
    Magnetic Fields

    Keywords

    • Magnetoencephalography
    • MEG-MRI
    • superconducting quantum interference device
    • ultra-low-field MRI

    Cite this

    Vesanen, P. T., Nieminen, J. O., Zevenhoven, K. C. J., Dabek, J., Parkkonen, L. T., Zhdanov, A. V., ... Ilmoniemi, R. J. (2013). Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. Magnetic Resonance in Medicine, 69(6), 1795-1804. https://doi.org/10.1002/mrm.24413
    Vesanen, P.T. ; Nieminen, J.O. ; Zevenhoven, K.C.J. ; Dabek, J. ; Parkkonen, L.T. ; Zhdanov, A.V. ; Luomahaara, Juho ; Hassel, Juha ; Penttilä, J. ; Simola, J. ; Ahonen, A.I. ; Mäkelä, J.P. ; Ilmoniemi, R.J. / Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. In: Magnetic Resonance in Medicine. 2013 ; Vol. 69, No. 6. pp. 1795-1804.
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    title = "Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer",
    abstract = "Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.",
    keywords = "Magnetoencephalography, MEG-MRI, superconducting quantum interference device, ultra-low-field MRI",
    author = "P.T. Vesanen and J.O. Nieminen and K.C.J. Zevenhoven and J. Dabek and L.T. Parkkonen and A.V. Zhdanov and Juho Luomahaara and Juha Hassel and J. Penttil{\"a} and J. Simola and A.I. Ahonen and J.P. M{\"a}kel{\"a} and R.J. Ilmoniemi",
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    Vesanen, PT, Nieminen, JO, Zevenhoven, KCJ, Dabek, J, Parkkonen, LT, Zhdanov, AV, Luomahaara, J, Hassel, J, Penttilä, J, Simola, J, Ahonen, AI, Mäkelä, JP & Ilmoniemi, RJ 2013, 'Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer', Magnetic Resonance in Medicine, vol. 69, no. 6, pp. 1795-1804. https://doi.org/10.1002/mrm.24413

    Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer. / Vesanen, P.T. (Corresponding Author); Nieminen, J.O.; Zevenhoven, K.C.J.; Dabek, J.; Parkkonen, L.T.; Zhdanov, A.V.; Luomahaara, Juho; Hassel, Juha; Penttilä, J.; Simola, J.; Ahonen, A.I.; Mäkelä, J.P.; Ilmoniemi, R.J.

    In: Magnetic Resonance in Medicine, Vol. 69, No. 6, 2013, p. 1795-1804.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

    AU - Vesanen, P.T.

    AU - Nieminen, J.O.

    AU - Zevenhoven, K.C.J.

    AU - Dabek, J.

    AU - Parkkonen, L.T.

    AU - Zhdanov, A.V.

    AU - Luomahaara, Juho

    AU - Hassel, Juha

    AU - Penttilä, J.

    AU - Simola, J.

    AU - Ahonen, A.I.

    AU - Mäkelä, J.P.

    AU - Ilmoniemi, R.J.

    PY - 2013

    Y1 - 2013

    N2 - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

    AB - Ultra‐low‐field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG‐MRI instrumentation based on a commercial whole‐head MEG device is described. The combination of ultra‐low‐field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG‐MRI measurements are described. The performance of the device is demonstrated by presenting ultra‐low‐field‐MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device.

    KW - Magnetoencephalography

    KW - MEG-MRI

    KW - superconducting quantum interference device

    KW - ultra-low-field MRI

    U2 - 10.1002/mrm.24413

    DO - 10.1002/mrm.24413

    M3 - Article

    VL - 69

    SP - 1795

    EP - 1804

    JO - Magnetic Resonance in Medicine

    JF - Magnetic Resonance in Medicine

    SN - 0740-3194

    IS - 6

    ER -