Hygiene requirements in the fermentation process

Ilkka Virkajärvi

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Abstract

Although modern control systems have made sterilisation of fermenters and fermentation media in a small scale very easy, understanding the system design may well help in finding the cause when problems arise. In larger fermentation systems understanding engineering solutions and the reasons behind them will be very valuable, if contamination problems occur. Valve systems configurations with steam traps play an important role in sterilisation of fermentation systems. Avoiding dead legs, remembering "six tubediameter" rule and the nature of hydrophobic membranes will help in successful fermentations. In this presentation system design is considered more than calculating times and temperatures to achieve a certain Z-value or calculating heat transfer across a fouling tubular heat exchanger used in continuous sterilisation. Calculations of this kind can be found for example in Raju and Cooney (1993). Some comments are also presented in comparing batch and continuous sterilisation of fermentation media.
Original languageEnglish
Title of host publication34th R3-Nordic Contamination Control Symposium
Place of PublicationEspoo
PublisherVTT Technical Research Centre of Finland
Pages133-144
ISBN (Electronic)951-38-6285-2
ISBN (Print)951-38-6284-4
Publication statusPublished - 2003
MoE publication typeB3 Non-refereed article in conference proceedings
Event34th R3-Nordic Contamination Control Symposium - Turku, Finland
Duration: 2 Jun 20034 Jun 2003

Publication series

NameVTT Symposium
PublisherVTT
Number229
ISSN (Print)0357-9387
ISSN (Electronic)1455-0873

Conference

Conference34th R3-Nordic Contamination Control Symposium
CountryFinland
CityTurku
Period2/06/034/06/03

Fingerprint

Fermentation
Steam separators and traps
Systems analysis
Fermenters
Fouling
Heat exchangers
Contamination
Heat transfer
Membranes
Control systems
Temperature

Cite this

Virkajärvi, I. (2003). Hygiene requirements in the fermentation process. In 34th R3-Nordic Contamination Control Symposium (pp. 133-144). Espoo: VTT Technical Research Centre of Finland. VTT Symposium, No. 229
Virkajärvi, Ilkka. / Hygiene requirements in the fermentation process. 34th R3-Nordic Contamination Control Symposium. Espoo : VTT Technical Research Centre of Finland, 2003. pp. 133-144 (VTT Symposium; No. 229).
@inproceedings{1626fc32c4704d4b8898dba1410a4ffe,
title = "Hygiene requirements in the fermentation process",
abstract = "Although modern control systems have made sterilisation of fermenters and fermentation media in a small scale very easy, understanding the system design may well help in finding the cause when problems arise. In larger fermentation systems understanding engineering solutions and the reasons behind them will be very valuable, if contamination problems occur. Valve systems configurations with steam traps play an important role in sterilisation of fermentation systems. Avoiding dead legs, remembering {"}six tubediameter{"} rule and the nature of hydrophobic membranes will help in successful fermentations. In this presentation system design is considered more than calculating times and temperatures to achieve a certain Z-value or calculating heat transfer across a fouling tubular heat exchanger used in continuous sterilisation. Calculations of this kind can be found for example in Raju and Cooney (1993). Some comments are also presented in comparing batch and continuous sterilisation of fermentation media.",
author = "Ilkka Virkaj{\"a}rvi",
year = "2003",
language = "English",
isbn = "951-38-6284-4",
series = "VTT Symposium",
publisher = "VTT Technical Research Centre of Finland",
number = "229",
pages = "133--144",
booktitle = "34th R3-Nordic Contamination Control Symposium",
address = "Finland",

}

Virkajärvi, I 2003, Hygiene requirements in the fermentation process. in 34th R3-Nordic Contamination Control Symposium. VTT Technical Research Centre of Finland, Espoo, VTT Symposium, no. 229, pp. 133-144, 34th R3-Nordic Contamination Control Symposium, Turku, Finland, 2/06/03.

Hygiene requirements in the fermentation process. / Virkajärvi, Ilkka.

34th R3-Nordic Contamination Control Symposium. Espoo : VTT Technical Research Centre of Finland, 2003. p. 133-144 (VTT Symposium; No. 229).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

TY - GEN

T1 - Hygiene requirements in the fermentation process

AU - Virkajärvi, Ilkka

PY - 2003

Y1 - 2003

N2 - Although modern control systems have made sterilisation of fermenters and fermentation media in a small scale very easy, understanding the system design may well help in finding the cause when problems arise. In larger fermentation systems understanding engineering solutions and the reasons behind them will be very valuable, if contamination problems occur. Valve systems configurations with steam traps play an important role in sterilisation of fermentation systems. Avoiding dead legs, remembering "six tubediameter" rule and the nature of hydrophobic membranes will help in successful fermentations. In this presentation system design is considered more than calculating times and temperatures to achieve a certain Z-value or calculating heat transfer across a fouling tubular heat exchanger used in continuous sterilisation. Calculations of this kind can be found for example in Raju and Cooney (1993). Some comments are also presented in comparing batch and continuous sterilisation of fermentation media.

AB - Although modern control systems have made sterilisation of fermenters and fermentation media in a small scale very easy, understanding the system design may well help in finding the cause when problems arise. In larger fermentation systems understanding engineering solutions and the reasons behind them will be very valuable, if contamination problems occur. Valve systems configurations with steam traps play an important role in sterilisation of fermentation systems. Avoiding dead legs, remembering "six tubediameter" rule and the nature of hydrophobic membranes will help in successful fermentations. In this presentation system design is considered more than calculating times and temperatures to achieve a certain Z-value or calculating heat transfer across a fouling tubular heat exchanger used in continuous sterilisation. Calculations of this kind can be found for example in Raju and Cooney (1993). Some comments are also presented in comparing batch and continuous sterilisation of fermentation media.

M3 - Conference article in proceedings

SN - 951-38-6284-4

T3 - VTT Symposium

SP - 133

EP - 144

BT - 34th R3-Nordic Contamination Control Symposium

PB - VTT Technical Research Centre of Finland

CY - Espoo

ER -

Virkajärvi I. Hygiene requirements in the fermentation process. In 34th R3-Nordic Contamination Control Symposium. Espoo: VTT Technical Research Centre of Finland. 2003. p. 133-144. (VTT Symposium; No. 229).