Although modern control systems have made sterilisation of fermenters
and fermentation media in a small scale very easy, understanding the system
design may well help in finding the cause when problems arise. In larger
fermentation systems understanding engineering solutions and the reasons
behind them will be very valuable, if contamination problems occur. Valve
systems configurations with steam traps play an important role in
sterilisation of fermentation systems. Avoiding dead legs, remembering "six
tubediameter" rule and the nature of hydrophobic membranes will help in
In this presentation system design is considered more than calculating times
and temperatures to achieve a certain Z-value or calculating heat transfer
across a fouling tubular heat exchanger used in continuous sterilisation.
Calculations of this kind can be found for example in Raju and Cooney (1993).
Some comments are also presented in comparing batch and continuous
sterilisation of fermentation media.
|Title of host publication||34th R3-Nordic Contamination Control Symposium|
|Place of Publication||Espoo|
|Publisher||VTT Technical Research Centre of Finland|
|Publication status||Published - 2003|
|MoE publication type||B3 Non-refereed article in conference proceedings|
|Event||34th R3-Nordic Contamination Control Symposium - Turku, Finland|
Duration: 2 Jun 2003 → 4 Jun 2003
|Conference||34th R3-Nordic Contamination Control Symposium|
|Period||2/06/03 → 4/06/03|