Hygrometer-based calibration method for syringe pumps providing ultra-low liquid flows

Hannu A. Sairanen (Corresponding Author), Martti O. Heinonen

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

Traceable and accurate measurements are critical in many areas where syringe pumps are used to provide microscale liquid flow. Especially, drug delivery demands for low flow rate calibrations have been increasing, but currently available calibration methods are very limited in range and accuracy at flow rates below 100 µl min-1. This paper presents a new hygrometer-based method for the calibration of syringe pumps providing traceability down to the 0.1 µl min-1 level. In this method, liquid water from the syringe pump under calibration is injected into a porous cloth from which it evaporates and mixes with a dry gas flow. By measuring the humidity, temperature, pressure and flow rate of the gas, the injected water flow rate can be calculated. To test the method, a calibration set-up was constructed and a syringe pump was calibrated at flow rates from 0.1 to 10 µl min-1. A thorough uncertainty analysis carried out as a part of the work shows that a relative uncertainty of 0.4 % (at 95 % confidence level) is achieved at the largest calibration flow rate. The uncertainty increases to 3.3 % towards low end of the flow rate range. The achieved uncertainty level is significantly better than achieved with gravimetric methods so far.
Original languageEnglish
Pages (from-to)187-193
JournalMicrofluidics and Nanofluidics
Volume16
Issue number1-2
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Hygrometers
hygrometers
syringes
Syringes
liquid flow
flow velocity
Flow rate
Pumps
Calibration
pumps
Liquids
Uncertainty analysis
Water
water flow
Drug delivery
microbalances
gas flow
Flow of gases
humidity
confidence

Keywords

  • microflow
  • nanoflow
  • syringe pumps
  • hygrometers
  • calibration
  • traceability

Cite this

Sairanen, Hannu A. ; Heinonen, Martti O. / Hygrometer-based calibration method for syringe pumps providing ultra-low liquid flows. In: Microfluidics and Nanofluidics. 2014 ; Vol. 16, No. 1-2. pp. 187-193.
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title = "Hygrometer-based calibration method for syringe pumps providing ultra-low liquid flows",
abstract = "Traceable and accurate measurements are critical in many areas where syringe pumps are used to provide microscale liquid flow. Especially, drug delivery demands for low flow rate calibrations have been increasing, but currently available calibration methods are very limited in range and accuracy at flow rates below 100 µl min-1. This paper presents a new hygrometer-based method for the calibration of syringe pumps providing traceability down to the 0.1 µl min-1 level. In this method, liquid water from the syringe pump under calibration is injected into a porous cloth from which it evaporates and mixes with a dry gas flow. By measuring the humidity, temperature, pressure and flow rate of the gas, the injected water flow rate can be calculated. To test the method, a calibration set-up was constructed and a syringe pump was calibrated at flow rates from 0.1 to 10 µl min-1. A thorough uncertainty analysis carried out as a part of the work shows that a relative uncertainty of 0.4 {\%} (at 95 {\%} confidence level) is achieved at the largest calibration flow rate. The uncertainty increases to 3.3 {\%} towards low end of the flow rate range. The achieved uncertainty level is significantly better than achieved with gravimetric methods so far.",
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Hygrometer-based calibration method for syringe pumps providing ultra-low liquid flows. / Sairanen, Hannu A. (Corresponding Author); Heinonen, Martti O.

In: Microfluidics and Nanofluidics, Vol. 16, No. 1-2, 2014, p. 187-193.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hygrometer-based calibration method for syringe pumps providing ultra-low liquid flows

AU - Sairanen, Hannu A.

AU - Heinonen, Martti O.

PY - 2014

Y1 - 2014

N2 - Traceable and accurate measurements are critical in many areas where syringe pumps are used to provide microscale liquid flow. Especially, drug delivery demands for low flow rate calibrations have been increasing, but currently available calibration methods are very limited in range and accuracy at flow rates below 100 µl min-1. This paper presents a new hygrometer-based method for the calibration of syringe pumps providing traceability down to the 0.1 µl min-1 level. In this method, liquid water from the syringe pump under calibration is injected into a porous cloth from which it evaporates and mixes with a dry gas flow. By measuring the humidity, temperature, pressure and flow rate of the gas, the injected water flow rate can be calculated. To test the method, a calibration set-up was constructed and a syringe pump was calibrated at flow rates from 0.1 to 10 µl min-1. A thorough uncertainty analysis carried out as a part of the work shows that a relative uncertainty of 0.4 % (at 95 % confidence level) is achieved at the largest calibration flow rate. The uncertainty increases to 3.3 % towards low end of the flow rate range. The achieved uncertainty level is significantly better than achieved with gravimetric methods so far.

AB - Traceable and accurate measurements are critical in many areas where syringe pumps are used to provide microscale liquid flow. Especially, drug delivery demands for low flow rate calibrations have been increasing, but currently available calibration methods are very limited in range and accuracy at flow rates below 100 µl min-1. This paper presents a new hygrometer-based method for the calibration of syringe pumps providing traceability down to the 0.1 µl min-1 level. In this method, liquid water from the syringe pump under calibration is injected into a porous cloth from which it evaporates and mixes with a dry gas flow. By measuring the humidity, temperature, pressure and flow rate of the gas, the injected water flow rate can be calculated. To test the method, a calibration set-up was constructed and a syringe pump was calibrated at flow rates from 0.1 to 10 µl min-1. A thorough uncertainty analysis carried out as a part of the work shows that a relative uncertainty of 0.4 % (at 95 % confidence level) is achieved at the largest calibration flow rate. The uncertainty increases to 3.3 % towards low end of the flow rate range. The achieved uncertainty level is significantly better than achieved with gravimetric methods so far.

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KW - nanoflow

KW - syringe pumps

KW - hygrometers

KW - calibration

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