Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact

Suvi-Katri Leivonen (Corresponding Author), Anne Rokka, Päivi Östling, Pekka Kohonen, Garry L. Corthals, Olli Kallioniemi, Merja Perälä

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49 Citations (Scopus)

Abstract

Identification of protein targets for microRNAs (miRNAs) is a significant challenge due to the complexity of miRNA-mediated regulation. We have previously demonstrated that miR-193b targets estrogen receptor-α (ERα) and inhibits estrogen-induced growth of breast cancer cells. Here, we applied a high-throughput strategy using quantitative iTRAQ (isobaric tag for relative and absolute quantitation) reagents to identify other target proteins regulated by miR-193b in breast cancer cells.
Original languageEnglish
JournalMolecular and Cellular Proteomics
Volume10
Issue number7
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

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