Impact of dietary polyphenols on carbohydrate metabolism

Kati Hanhineva (Corresponding Author), Riitta Törrönen, Isabel Bondia-Pons, Jenna Pekkinen, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen

Research output: Contribution to journalReview ArticleScientificpeer-review

503 Citations (Scopus)

Abstract

Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity. The possible mechanisms include inhibition of carbohydrate digestion and glucose absorption in the intestine, stimulation of insulin secretion from the pancreatic b-cells, modulation of glucose release from the liver, activation of insulin receptors and glucose uptake in the insulin-sensitive tissues, and modulation of intracellular signalling pathways and gene expression. The positive effects of polyphenols on glucose homeostasis observed in a large number of in vitro and animal models are supported by epidemiological evidence on polyphenol-rich diets. To confirm the implications of polyphenol consumption for prevention of insulin resistance, metabolic syndrome and eventually type 2 diabetes, human trials with well-defined diets, controlled study designs and clinically relevant end-points together with holistic approaches e.g., systems biology profiling technologies are needed.
Original languageEnglish
Pages (from-to)1365-1402
Number of pages38
JournalInternational Journal of Molecular Sciences
Volume11
Issue number4
DOIs
Publication statusPublished - 2010
MoE publication typeA2 Review article in a scientific journal

Fingerprint

carbohydrate metabolism
insulin
Carbohydrate Metabolism
Polyphenols
Insulin
glucose
Glucose
diets
secretions
animal models
food
Nutrition
hyperglycemia
fasting
Insulin Resistance
Fruit
Animals
coffee
beverages
Animal Models

Keywords

  • Diet
  • Glucose metabolism
  • Glycemic response
  • Insulin sensitivity
  • Phenolic compounds
  • Phytochemical
  • Polyphenols

Cite this

Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010). Impact of dietary polyphenols on carbohydrate metabolism. International Journal of Molecular Sciences, 11(4), 1365-1402. https://doi.org/10.3390/ijms11041365
Hanhineva, Kati ; Törrönen, Riitta ; Bondia-Pons, Isabel ; Pekkinen, Jenna ; Kolehmainen, Marjukka ; Mykkänen, Hannu ; Poutanen, Kaisa. / Impact of dietary polyphenols on carbohydrate metabolism. In: International Journal of Molecular Sciences. 2010 ; Vol. 11, No. 4. pp. 1365-1402.
@article{7b64447254424f1989d301147818e116,
title = "Impact of dietary polyphenols on carbohydrate metabolism",
abstract = "Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity. The possible mechanisms include inhibition of carbohydrate digestion and glucose absorption in the intestine, stimulation of insulin secretion from the pancreatic b-cells, modulation of glucose release from the liver, activation of insulin receptors and glucose uptake in the insulin-sensitive tissues, and modulation of intracellular signalling pathways and gene expression. The positive effects of polyphenols on glucose homeostasis observed in a large number of in vitro and animal models are supported by epidemiological evidence on polyphenol-rich diets. To confirm the implications of polyphenol consumption for prevention of insulin resistance, metabolic syndrome and eventually type 2 diabetes, human trials with well-defined diets, controlled study designs and clinically relevant end-points together with holistic approaches e.g., systems biology profiling technologies are needed.",
keywords = "Diet, Glucose metabolism, Glycemic response, Insulin sensitivity, Phenolic compounds, Phytochemical, Polyphenols",
author = "Kati Hanhineva and Riitta T{\"o}rr{\"o}nen and Isabel Bondia-Pons and Jenna Pekkinen and Marjukka Kolehmainen and Hannu Mykk{\"a}nen and Kaisa Poutanen",
year = "2010",
doi = "10.3390/ijms11041365",
language = "English",
volume = "11",
pages = "1365--1402",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI",
number = "4",

}

Hanhineva, K, Törrönen, R, Bondia-Pons, I, Pekkinen, J, Kolehmainen, M, Mykkänen, H & Poutanen, K 2010, 'Impact of dietary polyphenols on carbohydrate metabolism', International Journal of Molecular Sciences, vol. 11, no. 4, pp. 1365-1402. https://doi.org/10.3390/ijms11041365

Impact of dietary polyphenols on carbohydrate metabolism. / Hanhineva, Kati (Corresponding Author); Törrönen, Riitta; Bondia-Pons, Isabel; Pekkinen, Jenna; Kolehmainen, Marjukka; Mykkänen, Hannu; Poutanen, Kaisa.

In: International Journal of Molecular Sciences, Vol. 11, No. 4, 2010, p. 1365-1402.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Impact of dietary polyphenols on carbohydrate metabolism

AU - Hanhineva, Kati

AU - Törrönen, Riitta

AU - Bondia-Pons, Isabel

AU - Pekkinen, Jenna

AU - Kolehmainen, Marjukka

AU - Mykkänen, Hannu

AU - Poutanen, Kaisa

PY - 2010

Y1 - 2010

N2 - Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity. The possible mechanisms include inhibition of carbohydrate digestion and glucose absorption in the intestine, stimulation of insulin secretion from the pancreatic b-cells, modulation of glucose release from the liver, activation of insulin receptors and glucose uptake in the insulin-sensitive tissues, and modulation of intracellular signalling pathways and gene expression. The positive effects of polyphenols on glucose homeostasis observed in a large number of in vitro and animal models are supported by epidemiological evidence on polyphenol-rich diets. To confirm the implications of polyphenol consumption for prevention of insulin resistance, metabolic syndrome and eventually type 2 diabetes, human trials with well-defined diets, controlled study designs and clinically relevant end-points together with holistic approaches e.g., systems biology profiling technologies are needed.

AB - Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity. The possible mechanisms include inhibition of carbohydrate digestion and glucose absorption in the intestine, stimulation of insulin secretion from the pancreatic b-cells, modulation of glucose release from the liver, activation of insulin receptors and glucose uptake in the insulin-sensitive tissues, and modulation of intracellular signalling pathways and gene expression. The positive effects of polyphenols on glucose homeostasis observed in a large number of in vitro and animal models are supported by epidemiological evidence on polyphenol-rich diets. To confirm the implications of polyphenol consumption for prevention of insulin resistance, metabolic syndrome and eventually type 2 diabetes, human trials with well-defined diets, controlled study designs and clinically relevant end-points together with holistic approaches e.g., systems biology profiling technologies are needed.

KW - Diet

KW - Glucose metabolism

KW - Glycemic response

KW - Insulin sensitivity

KW - Phenolic compounds

KW - Phytochemical

KW - Polyphenols

U2 - 10.3390/ijms11041365

DO - 10.3390/ijms11041365

M3 - Review Article

VL - 11

SP - 1365

EP - 1402

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 4

ER -

Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H et al. Impact of dietary polyphenols on carbohydrate metabolism. International Journal of Molecular Sciences. 2010;11(4):1365-1402. https://doi.org/10.3390/ijms11041365