Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice

N.N. Rosa, J. Pekkinen, K. Zavala, G. Fouret, A. Korkmaz, C. Feillet-Coudray, M. Atalay, H. Mykkänen, Kaisa Poutanen, V. Micard (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
Original languageEnglish
Pages (from-to)10101-10109
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number41
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

metabolic diseases
High Fat Diet
high fat diet
Nutrition
Triticum
Fats
Diet
Weight Gain
wheat
weight gain
Body Weight
mice
Leptin
leptin
diet
body weight
fasting
Fasting
obesity
insulin

Keywords

  • oxidative stress
  • aleurone
  • enzymatic treatments
  • high-fat diet
  • metabolic disorders
  • obesity

Cite this

Rosa, N. N., Pekkinen, J., Zavala, K., Fouret, G., Korkmaz, A., Feillet-Coudray, C., ... Micard, V. (2014). Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice. Journal of Agricultural and Food Chemistry, 62(41), 10101-10109. https://doi.org/10.1021/jf503314a
Rosa, N.N. ; Pekkinen, J. ; Zavala, K. ; Fouret, G. ; Korkmaz, A. ; Feillet-Coudray, C. ; Atalay, M. ; Mykkänen, H. ; Poutanen, Kaisa ; Micard, V. / Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice. In: Journal of Agricultural and Food Chemistry. 2014 ; Vol. 62, No. 41. pp. 10101-10109.
@article{3abb962e3bea4bb1a39f1e5f2e1ab1f2,
title = "Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice",
abstract = "The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13{\%} (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.",
keywords = "oxidative stress, aleurone, enzymatic treatments, high-fat diet, metabolic disorders, obesity",
author = "N.N. Rosa and J. Pekkinen and K. Zavala and G. Fouret and A. Korkmaz and C. Feillet-Coudray and M. Atalay and H. Mykk{\"a}nen and Kaisa Poutanen and V. Micard",
year = "2014",
doi = "10.1021/jf503314a",
language = "English",
volume = "62",
pages = "10101--10109",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society ACS",
number = "41",

}

Rosa, NN, Pekkinen, J, Zavala, K, Fouret, G, Korkmaz, A, Feillet-Coudray, C, Atalay, M, Mykkänen, H, Poutanen, K & Micard, V 2014, 'Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice', Journal of Agricultural and Food Chemistry, vol. 62, no. 41, pp. 10101-10109. https://doi.org/10.1021/jf503314a

Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice. / Rosa, N.N.; Pekkinen, J.; Zavala, K.; Fouret, G.; Korkmaz, A.; Feillet-Coudray, C.; Atalay, M.; Mykkänen, H.; Poutanen, Kaisa; Micard, V. (Corresponding Author).

In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 41, 2014, p. 10101-10109.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice

AU - Rosa, N.N.

AU - Pekkinen, J.

AU - Zavala, K.

AU - Fouret, G.

AU - Korkmaz, A.

AU - Feillet-Coudray, C.

AU - Atalay, M.

AU - Mykkänen, H.

AU - Poutanen, Kaisa

AU - Micard, V.

PY - 2014

Y1 - 2014

N2 - The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.

AB - The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.

KW - oxidative stress

KW - aleurone

KW - enzymatic treatments

KW - high-fat diet

KW - metabolic disorders

KW - obesity

U2 - 10.1021/jf503314a

DO - 10.1021/jf503314a

M3 - Article

VL - 62

SP - 10101

EP - 10109

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 41

ER -