Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice

N.N. Rosa, J. Pekkinen, K. Zavala, G. Fouret, A. Korkmaz, C. Feillet-Coudray, M. Atalay, H. Mykkänen, Kaisa Poutanen, V. Micard (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)


The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
Original languageEnglish
Pages (from-to)10101-10109
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number41
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed


  • oxidative stress
  • aleurone
  • enzymatic treatments
  • high-fat diet
  • metabolic disorders
  • obesity

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