The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
- oxidative stress
- enzymatic treatments
- high-fat diet
- metabolic disorders
Rosa, N. N., Pekkinen, J., Zavala, K., Fouret, G., Korkmaz, A., Feillet-Coudray, C., Atalay, M., Mykkänen, H., Poutanen, K., & Micard, V. (2014). Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice. Journal of Agricultural and Food Chemistry, 62(41), 10101-10109. https://doi.org/10.1021/jf503314a