Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice

Natalia Nicole Rosa, Jenna Pekkinen, Karla Zavala, Gilles Fouret, Ayhan Korkmaz, Christine Feillet-Coudray, Mustafa Atalay, Kati Hanhineva, Hannu Mykkänen, Kaisa Poutanen, Valérie Micard (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    16 Citations (Scopus)


    The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
    Original languageEnglish
    Pages (from-to)10101-10109
    JournalJournal of Agricultural and Food Chemistry
    Issue number41
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed


    • oxidative stress
    • aleurone
    • enzymatic treatments
    • high-fat diet
    • metabolic disorders
    • obesity


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