In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes; Lennart Richter; Jane Müller; Alexander Denisiuk; Sven C. Feifel; Yuquan Xu; Patricia Espinosa-Artiles; Roderich D. Süssmuth; István Molnár

doi:10.1039/c2cc31669b

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C. Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D. Süssmuth (Corresponding Author), István Molnár (Corresponding Author)

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34 Citations (Scopus)

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Original language	English
Pages (from-to)	5674-5676
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	45
DOIs	https://doi.org/10.1039/c2cc31669b
Publication status	Published - 9 May 2012
MoE publication type	A1 Journal article-refereed

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AU - Matthes, Diana

AU - Richter, Lennart

AU - Müller, Jane

AU - Denisiuk, Alexander

AU - Feifel, Sven C.

AU - Xu, Yuquan

AU - Espinosa-Artiles, Patricia

AU - Süssmuth, Roderich D.

AU - Molnár, István

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AB - New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

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In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Abstract

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