In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes; Lennart Richter; Jane Müller; Alexander Denisiuk; Sven C. Feifel; Yuquan Xu; Patricia Espinosa-Artiles; Roderich D. Süssmuth; István Molnár

doi:10.1039/c2cc31669b

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes
, Lennart Richter
, Jane Müller
, Alexander Denisiuk
, Sven C. Feifel
, Yuquan Xu
, Patricia Espinosa-Artiles
, Roderich D. Süssmuth^*
, István Molnár^*

^*Corresponding author for this work

Not published at VTT

Technical University of Berlin
University of Arizona

Research output: Contribution to journal › Article › Scientific › peer-review

35 Citations (Scopus)

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Original language	English
Pages (from-to)	5674-5676
Journal	Chemical Communications
Volume	48
Issue number	45
DOIs	https://doi.org/10.1039/c2cc31669b
Publication status	Published - 9 May 2012
MoE publication type	A1 Journal article-refereed

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10.1039/c2cc31669b

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abstract = "New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.",

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T1 - In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

AU - Matthes, Diana

AU - Richter, Lennart

AU - Müller, Jane

AU - Denisiuk, Alexander

AU - Feifel, Sven C.

AU - Xu, Yuquan

AU - Espinosa-Artiles, Patricia

AU - Süssmuth, Roderich D.

AU - Molnár, István

PY - 2012/5/9

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N2 - New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

AB - New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

UR - https://www.scopus.com/pages/publications/84862099557

U2 - 10.1039/c2cc31669b

DO - 10.1039/c2cc31669b

M3 - Article

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AN - SCOPUS:84862099557

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VL - 48

SP - 5674

EP - 5676

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Abstract

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