In vitro colon model to study metabolic syndrome

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

1 Citation (Scopus)

Abstract

Metabolic syndrome (MetS) is a metabolic disorder, tightly linked to obesity, and predisposing to cardiovascular disease and type-2 diabetes mellitus (T2D). There is already some knowledge related to intake of diet rich in phytochemicals and improved biological effects e.g. adipose tissue function or biomarkers of improved insulin sensitivity. This chapter aims to describe the connection between plant food and beverage intake and circulating metabolites by using the in vitro colon model. The in vitro colon model coupled with metabolomic systems biology is applied to connect food components, over-expressed in vitro metabolite profiles and corresponding in vivo metabolite profiles. When the diet relation has been made, the same metabolites are identified from the human body fluids. The traditional end-points related to health and disease can be connected with the biomarkers of intake of the same volunteers. Finally, novel biomarkers of health status can be sought using novel lipidomic and proteomic techniques, which has potential to answer to the urgent need for early biomarkers of disease and improved health.
Original languageEnglish
Title of host publicationA Systems Biology Approach to Study Metabolic Syndrome
EditorsMatej Orešič, Antonio Vidal-Puig
PublisherSpringer
Pages251 - 278
ISBN (Electronic)978-3-319-01008-3
ISBN (Print)978-3-319-01007-6
DOIs
Publication statusPublished - 2014
MoE publication typeD2 Article in professional manuals or guides or professional information systems or text book material

Fingerprint

Colon
Biomarkers
Diet
Food and Beverages
Metabolomics
Systems Biology
Health
Phytochemicals
Body Fluids
Human Body
Proteomics
Type 2 Diabetes Mellitus
Health Status
Insulin Resistance
Adipose Tissue
Volunteers
Cardiovascular Diseases
Obesity
Eating
Food

Keywords

  • Metabolic syndrome
  • Colonic metabolism and in vitro digestion models
  • Flavanols and proanthocyanins
  • Hydroxycinnamic acids
  • Anthocyanins

Cite this

Aura, A-M. (2014). In vitro colon model to study metabolic syndrome. In M. Orešič, & A. Vidal-Puig (Eds.), A Systems Biology Approach to Study Metabolic Syndrome (pp. 251 - 278). Springer. https://doi.org/10.1007/978-3-319-01008-3_13
Aura, Anna-Marja. / In vitro colon model to study metabolic syndrome. A Systems Biology Approach to Study Metabolic Syndrome. editor / Matej Orešič ; Antonio Vidal-Puig. Springer, 2014. pp. 251 - 278
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Aura, A-M 2014, In vitro colon model to study metabolic syndrome. in M Orešič & A Vidal-Puig (eds), A Systems Biology Approach to Study Metabolic Syndrome. Springer, pp. 251 - 278. https://doi.org/10.1007/978-3-319-01008-3_13

In vitro colon model to study metabolic syndrome. / Aura, Anna-Marja.

A Systems Biology Approach to Study Metabolic Syndrome. ed. / Matej Orešič; Antonio Vidal-Puig. Springer, 2014. p. 251 - 278.

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

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N2 - Metabolic syndrome (MetS) is a metabolic disorder, tightly linked to obesity, and predisposing to cardiovascular disease and type-2 diabetes mellitus (T2D). There is already some knowledge related to intake of diet rich in phytochemicals and improved biological effects e.g. adipose tissue function or biomarkers of improved insulin sensitivity. This chapter aims to describe the connection between plant food and beverage intake and circulating metabolites by using the in vitro colon model. The in vitro colon model coupled with metabolomic systems biology is applied to connect food components, over-expressed in vitro metabolite profiles and corresponding in vivo metabolite profiles. When the diet relation has been made, the same metabolites are identified from the human body fluids. The traditional end-points related to health and disease can be connected with the biomarkers of intake of the same volunteers. Finally, novel biomarkers of health status can be sought using novel lipidomic and proteomic techniques, which has potential to answer to the urgent need for early biomarkers of disease and improved health.

AB - Metabolic syndrome (MetS) is a metabolic disorder, tightly linked to obesity, and predisposing to cardiovascular disease and type-2 diabetes mellitus (T2D). There is already some knowledge related to intake of diet rich in phytochemicals and improved biological effects e.g. adipose tissue function or biomarkers of improved insulin sensitivity. This chapter aims to describe the connection between plant food and beverage intake and circulating metabolites by using the in vitro colon model. The in vitro colon model coupled with metabolomic systems biology is applied to connect food components, over-expressed in vitro metabolite profiles and corresponding in vivo metabolite profiles. When the diet relation has been made, the same metabolites are identified from the human body fluids. The traditional end-points related to health and disease can be connected with the biomarkers of intake of the same volunteers. Finally, novel biomarkers of health status can be sought using novel lipidomic and proteomic techniques, which has potential to answer to the urgent need for early biomarkers of disease and improved health.

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Aura A-M. In vitro colon model to study metabolic syndrome. In Orešič M, Vidal-Puig A, editors, A Systems Biology Approach to Study Metabolic Syndrome. Springer. 2014. p. 251 - 278 https://doi.org/10.1007/978-3-319-01008-3_13