Abstract
| Original language | English |
|---|---|
| Title of host publication | A Systems Biology Approach to Study Metabolic Syndrome |
| Editors | Matej Orešič, Antonio Vidal-Puig |
| Publisher | Springer |
| Pages | 251 - 278 |
| ISBN (Electronic) | 978-3-319-01008-3 |
| ISBN (Print) | 978-3-319-01007-6 |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | D2 Article in professional manuals or guides or professional information systems or text book material |
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Keywords
- Metabolic syndrome
- Colonic metabolism and in vitro digestion models
- Flavanols and proanthocyanins
- Hydroxycinnamic acids
- Anthocyanins
Cite this
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In vitro colon model to study metabolic syndrome. / Aura, Anna-Marja.
A Systems Biology Approach to Study Metabolic Syndrome. ed. / Matej Orešič; Antonio Vidal-Puig. Springer, 2014. p. 251 - 278.Research output: Chapter in Book/Report/Conference proceeding › Chapter or book article › Professional
TY - CHAP
T1 - In vitro colon model to study metabolic syndrome
AU - Aura, Anna-Marja
PY - 2014
Y1 - 2014
N2 - Metabolic syndrome (MetS) is a metabolic disorder, tightly linked to obesity, and predisposing to cardiovascular disease and type-2 diabetes mellitus (T2D). There is already some knowledge related to intake of diet rich in phytochemicals and improved biological effects e.g. adipose tissue function or biomarkers of improved insulin sensitivity. This chapter aims to describe the connection between plant food and beverage intake and circulating metabolites by using the in vitro colon model. The in vitro colon model coupled with metabolomic systems biology is applied to connect food components, over-expressed in vitro metabolite profiles and corresponding in vivo metabolite profiles. When the diet relation has been made, the same metabolites are identified from the human body fluids. The traditional end-points related to health and disease can be connected with the biomarkers of intake of the same volunteers. Finally, novel biomarkers of health status can be sought using novel lipidomic and proteomic techniques, which has potential to answer to the urgent need for early biomarkers of disease and improved health.
AB - Metabolic syndrome (MetS) is a metabolic disorder, tightly linked to obesity, and predisposing to cardiovascular disease and type-2 diabetes mellitus (T2D). There is already some knowledge related to intake of diet rich in phytochemicals and improved biological effects e.g. adipose tissue function or biomarkers of improved insulin sensitivity. This chapter aims to describe the connection between plant food and beverage intake and circulating metabolites by using the in vitro colon model. The in vitro colon model coupled with metabolomic systems biology is applied to connect food components, over-expressed in vitro metabolite profiles and corresponding in vivo metabolite profiles. When the diet relation has been made, the same metabolites are identified from the human body fluids. The traditional end-points related to health and disease can be connected with the biomarkers of intake of the same volunteers. Finally, novel biomarkers of health status can be sought using novel lipidomic and proteomic techniques, which has potential to answer to the urgent need for early biomarkers of disease and improved health.
KW - Metabolic syndrome
KW - Colonic metabolism and in vitro digestion models
KW - Flavanols and proanthocyanins
KW - Hydroxycinnamic acids
KW - Anthocyanins
U2 - 10.1007/978-3-319-01008-3_13
DO - 10.1007/978-3-319-01008-3_13
M3 - Chapter or book article
SN - 978-3-319-01007-6
SP - 251
EP - 278
BT - A Systems Biology Approach to Study Metabolic Syndrome
A2 - Orešič, Matej
A2 - Vidal-Puig, Antonio
PB - Springer
ER -