Abstract
The laser has biomodulation effects on blood properties thus could regulate the microcirculation. The laser-RBC interaction mechanism is unclear, whereas most studies provide statistical results and lack detailed observations of laser irradiation effects on blood rheology. This study is designated to probe the in vitro effects of 520 nm diode laser irradiation on red blood cells (RBCs) mutual interaction properties in spontaneous aggregation process in autologous plasma by optical tweezers (OTs), with an attempt to reveal the laser-RBC interaction outcomes at a single-cell level. The results preliminarily show that though the laser irradiation statistically inhibited the increase of the size of RBC aggregates compared with the non-irradiating group, the aggregation force between single RBCs increased slightly with the time of irradiation.
Original language | English |
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Title of host publication | Optical Trapping and Optical Micromanipulation XVIII |
Editors | Kishan Dholakia, Gabriel C. Spalding |
Publisher | International Society for Optics and Photonics SPIE |
ISBN (Electronic) | 978-1-5106-4435-9 |
ISBN (Print) | 978-1-5106-4434-2 |
DOIs | |
Publication status | Published - 2021 |
MoE publication type | A4 Article in a conference publication |
Event | Optical Trapping and Optical Micromanipulation XVIII 2021 - San Diego, United States Duration: 1 Aug 2021 → 5 Aug 2021 |
Publication series
Series | Proceedings of SPIE |
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Volume | 11798 |
ISSN | 0277-786X |
Conference
Conference | Optical Trapping and Optical Micromanipulation XVIII 2021 |
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Country/Territory | United States |
City | San Diego |
Period | 1/08/21 → 5/08/21 |
Funding
This work was partially funded by the China Scholarship Council (CSC No. 201706410089, R.Z.). R.Z. acknowledges X.Y. Su (School of Science, Beijing Jiaotong University, Beijing, China) for technical help in laser irradiation source selection. The authors also acknowledge the contribution of Russian Science Foundation (Projects: 19-72-30012 and 20-64-46003). I.M. acknowledges partial support from the Academy of Finland (project 325,097).
Keywords
- laser irradiation
- light microscopy
- optical tweezers
- RBC aggregation
- Red blood cells (RBCs)