TY - JOUR
T1 - In vivo detection of vascular adhesion protein-1 in experimental inflammation
AU - Jaakkola, Kimmo
AU - Nikula, Tuomo
AU - Holopainen, Riikka
AU - Vähäsilta, Tommi
AU - Matikainen, Marja-Terttu
AU - Laukkanen, Marja-Leena
AU - Huupponen, Risto
AU - Halkola, Lauri
AU - Nieminen, Lauri
AU - Hiltunen, Jukka
AU - Parviainen, Sakari
AU - Clark, Michael
AU - Knuuti, Juhani
AU - Savunen, Timo
AU - Kääpä, Pekka
AU - Voipio-Pulkki, Liisa
AU - Jalkanen, Sirpa
PY - 2000
Y1 - 2000
N2 - Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial glycoprotein which mediates leukocyte-endothelial cell interactions. To study the pathogenetic significance of VAP-1 in inflammatory disorders, an in vivo immunodetection method was used to detect the regulation of luminally expressed VAP-1 in experimental skin and joint inflammation
in the pig and dog. Moreover, VAP-1 was studied as a potential target
to localize inflammation by radioimmunoscintigraphy. Up-regulation of
VAP-1 in experimental dermatitis
and arthritis could be visualized by specifically targeted
immunoscintigraphy. Moreover, the translocation of VAP-1 to the
functional position on the endothelial surface was only seen in inflamed
tissues. These results suggest that VAP-1 is both an optimal candidate
for anti-adhesive therapy and a potential target molecule for imaging
inflammation.
AB - Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial glycoprotein which mediates leukocyte-endothelial cell interactions. To study the pathogenetic significance of VAP-1 in inflammatory disorders, an in vivo immunodetection method was used to detect the regulation of luminally expressed VAP-1 in experimental skin and joint inflammation
in the pig and dog. Moreover, VAP-1 was studied as a potential target
to localize inflammation by radioimmunoscintigraphy. Up-regulation of
VAP-1 in experimental dermatitis
and arthritis could be visualized by specifically targeted
immunoscintigraphy. Moreover, the translocation of VAP-1 to the
functional position on the endothelial surface was only seen in inflamed
tissues. These results suggest that VAP-1 is both an optimal candidate
for anti-adhesive therapy and a potential target molecule for imaging
inflammation.
U2 - 10.1016/S0002-9440(10)64558-0
DO - 10.1016/S0002-9440(10)64558-0
M3 - Article
SN - 0002-9440
VL - 157
SP - 463 471
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 2
ER -