Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

Merja Penttilä*, Marja Sorsa, Harri Vainio

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalToxicology Letters
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Jan 1980
MoE publication typeA1 Journal article-refereed

Funding

This study was supported by the National Research Council for Sciences (Academy of Finland).

Fingerprint

Dive into the research topics of 'Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster'. Together they form a unique fingerprint.

Cite this