Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

Merja Penttilä; Marja Sorsa; Harri Vainio

doi:10.1016/0378-4274(80)90178-2

Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

Merja Penttilä, Marja Sorsa, Harri Vainio

Not published at VTT

Finnish Institute of Occupational Health (FIOH)

Research output: Contribution to journal › Article › Scientific › peer-review

20 Citations (Scopus)

Abstract

Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.

Original language	English
Pages (from-to)	119-123
Number of pages	5
Journal	Toxicology Letters
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(80)90178-2
Publication status	Published - 1 Jan 1980
MoE publication type	A1 Journal article-refereed

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abstract = "Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.",

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AU - Sorsa, Marja

AU - Vainio, Harri

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N2 - Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.

AB - Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.

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Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

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