Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

Merja Penttilä, Marja Sorsa, Harri Vainio

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Abstract

Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalToxicology Letters
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Jan 1980
MoE publication typeA1 Journal article-refereed

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Micronucleus Tests
Styrene
Cricetulus
Drosophila
styrene oxide
Chromosomes
Sex Chromosomes
Metabolites
Drosophila melanogaster
Bone
Bone Marrow

Cite this

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title = "Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster",
abstract = "Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 mg/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.",
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Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster. / Penttilä, Merja; Sorsa, Marja; Vainio, Harri.

In: Toxicology Letters, Vol. 6, No. 2, 01.01.1980, p. 119-123.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster

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