Indole alkaloid production by hairy root cultures of catharanthus roseus: Growth kinetics and fermentation

Leena Toivonen, Marja Ojala, Veli Kauppinen

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Growth kinetics and indole alkaloid production ofCatharanthus roseus hairy root cultures were studied in shake flasks and in a small scale fermenter. A logistic growth model commonly used for microbes described well the growth of hairy roots. Of the several parameters analyzed during the cultivation of hairy roots, a linear relationship between sucrose consumption and dry weight increase was obtained. This suggests the validity of sugar analysis as a means in monitoring the growth of hairy roots in fermenters.
Original languageEnglish
Pages (from-to)519-524
JournalBiotechnology Letters
Issue number7
Publication statusPublished - 1990
MoE publication typeA1 Journal article-refereed


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