Indole alkaloid production by hairy root cultures of catharanthus roseus

Growth kinetics and fermentation

Leena Toivonen, Marja Ojala, Veli Kauppinen

Research output: Contribution to journalArticleScientificpeer-review

29 Citations (Scopus)

Abstract

Growth kinetics and indole alkaloid production ofCatharanthus roseus hairy root cultures were studied in shake flasks and in a small scale fermenter. A logistic growth model commonly used for microbes described well the growth of hairy roots. Of the several parameters analyzed during the cultivation of hairy roots, a linear relationship between sucrose consumption and dry weight increase was obtained. This suggests the validity of sugar analysis as a means in monitoring the growth of hairy roots in fermenters.
Original languageEnglish
Pages (from-to)519-524
JournalBiotechnology Letters
Volume12
Issue number7
DOIs
Publication statusPublished - 1990
MoE publication typeA1 Journal article-refereed

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Catharanthus
Indole Alkaloids
Alkaloids
Growth kinetics
Fermentation
Fermenters
Growth
Sugar (sucrose)
Sugars
Sucrose
Logistics
Monitoring
Logistic Models
Weights and Measures

Cite this

Toivonen, Leena ; Ojala, Marja ; Kauppinen, Veli. / Indole alkaloid production by hairy root cultures of catharanthus roseus : Growth kinetics and fermentation. In: Biotechnology Letters. 1990 ; Vol. 12, No. 7. pp. 519-524.
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abstract = "Growth kinetics and indole alkaloid production ofCatharanthus roseus hairy root cultures were studied in shake flasks and in a small scale fermenter. A logistic growth model commonly used for microbes described well the growth of hairy roots. Of the several parameters analyzed during the cultivation of hairy roots, a linear relationship between sucrose consumption and dry weight increase was obtained. This suggests the validity of sugar analysis as a means in monitoring the growth of hairy roots in fermenters.",
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Indole alkaloid production by hairy root cultures of catharanthus roseus : Growth kinetics and fermentation. / Toivonen, Leena; Ojala, Marja; Kauppinen, Veli.

In: Biotechnology Letters, Vol. 12, No. 7, 1990, p. 519-524.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Indole alkaloid production by hairy root cultures of catharanthus roseus

T2 - Growth kinetics and fermentation

AU - Toivonen, Leena

AU - Ojala, Marja

AU - Kauppinen, Veli

PY - 1990

Y1 - 1990

N2 - Growth kinetics and indole alkaloid production ofCatharanthus roseus hairy root cultures were studied in shake flasks and in a small scale fermenter. A logistic growth model commonly used for microbes described well the growth of hairy roots. Of the several parameters analyzed during the cultivation of hairy roots, a linear relationship between sucrose consumption and dry weight increase was obtained. This suggests the validity of sugar analysis as a means in monitoring the growth of hairy roots in fermenters.

AB - Growth kinetics and indole alkaloid production ofCatharanthus roseus hairy root cultures were studied in shake flasks and in a small scale fermenter. A logistic growth model commonly used for microbes described well the growth of hairy roots. Of the several parameters analyzed during the cultivation of hairy roots, a linear relationship between sucrose consumption and dry weight increase was obtained. This suggests the validity of sugar analysis as a means in monitoring the growth of hairy roots in fermenters.

U2 - 10.1007/BF01086346

DO - 10.1007/BF01086346

M3 - Article

VL - 12

SP - 519

EP - 524

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 7

ER -