Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome

Petteri Kallio, Marjukka Kolehmainen, David E. Laaksonen, Leena Pulkkinen, Mustafa Atalay, Hannu Mykkänen, Matti Uusitupa, Kaisa Poutanen, Leo Niskanen

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Abstract

BACKGROUND: Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus. OBJECTIVE: We hypothesized that dietary carbohydrates characterized by different postprandial insulin responses may differentially modify cytokine concentrations in plasma and gene expression in subcutaneous adipose tissue. DESIGN: Individuals (n = 47) with the metabolic syndrome were randomly assigned to a 12-wk diet with oat and wheat bread and potato (high postprandial insulin response) or rye bread and pasta (low postprandial insulin response). Postprandial glucose and insulin responses to the oat and wheat bread meal and to the rye bread meal were determined in 19 individuals before intervention. RESULTS: During the 12-wk diet, the change in the gene expression of interleukin (IL)-10 receptor alpha and tumor necrosis factor-alpha in subcutaneous adipose tissue differed between the groups (P = 0.002 and P = 0.083, respectively). Moreover, the change in fasting plasma concentrations of IL-1beta and IL-6 differed between the groups (P = 0.020 and P = 0.055, respectively). In the postprandial challenge, the insulin response to the rye bread meal was lower than that to the oat and wheat bread meal (P < 0.001), whereas there were no differences in the mean blood glucose response. In contrast, plasma glucose concentrations decreased more below fasting concentrations 2.5-3 h after the oat and wheat bread meal than after the rye bread meal. A late postprandial rebound of free fatty acids was detected after the oat and wheat bread meal (P = 0.048). CONCLUSIONS: Long-term intake of cereal foods with differing postprandial insulin responses may be a factor that modulates the inflammatory status in individuals with the metabolic syndrome.
Original languageEnglish
Pages (from-to)1497-1503
Number of pages7
JournalThe American journal of clinical nutrition
Volume87
Issue number5
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

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Bread
Insulin
Meals
Diet
Inflammation
Triticum
Subcutaneous Fat
Glucose
Fasting
Interleukin-10 Receptors
Dietary Carbohydrates
Gene Expression
Solanum tuberosum
Interleukin-1beta
Nonesterified Fatty Acids
Type 2 Diabetes Mellitus
Blood Glucose
Interleukin-6
Tumor Necrosis Factor-alpha
Eating

Keywords

  • Gene-nutrient interactions
  • adipose tissue
  • inflammation
  • cytokines
  • postprandial response

Cite this

Kallio, Petteri ; Kolehmainen, Marjukka ; Laaksonen, David E. ; Pulkkinen, Leena ; Atalay, Mustafa ; Mykkänen, Hannu ; Uusitupa, Matti ; Poutanen, Kaisa ; Niskanen, Leo. / Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. In: The American journal of clinical nutrition. 2008 ; Vol. 87, No. 5. pp. 1497-1503.
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abstract = "BACKGROUND: Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus. OBJECTIVE: We hypothesized that dietary carbohydrates characterized by different postprandial insulin responses may differentially modify cytokine concentrations in plasma and gene expression in subcutaneous adipose tissue. DESIGN: Individuals (n = 47) with the metabolic syndrome were randomly assigned to a 12-wk diet with oat and wheat bread and potato (high postprandial insulin response) or rye bread and pasta (low postprandial insulin response). Postprandial glucose and insulin responses to the oat and wheat bread meal and to the rye bread meal were determined in 19 individuals before intervention. RESULTS: During the 12-wk diet, the change in the gene expression of interleukin (IL)-10 receptor alpha and tumor necrosis factor-alpha in subcutaneous adipose tissue differed between the groups (P = 0.002 and P = 0.083, respectively). Moreover, the change in fasting plasma concentrations of IL-1beta and IL-6 differed between the groups (P = 0.020 and P = 0.055, respectively). In the postprandial challenge, the insulin response to the rye bread meal was lower than that to the oat and wheat bread meal (P < 0.001), whereas there were no differences in the mean blood glucose response. In contrast, plasma glucose concentrations decreased more below fasting concentrations 2.5-3 h after the oat and wheat bread meal than after the rye bread meal. A late postprandial rebound of free fatty acids was detected after the oat and wheat bread meal (P = 0.048). CONCLUSIONS: Long-term intake of cereal foods with differing postprandial insulin responses may be a factor that modulates the inflammatory status in individuals with the metabolic syndrome.",
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Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. / Kallio, Petteri; Kolehmainen, Marjukka; Laaksonen, David E.; Pulkkinen, Leena; Atalay, Mustafa; Mykkänen, Hannu; Uusitupa, Matti; Poutanen, Kaisa; Niskanen, Leo.

In: The American journal of clinical nutrition, Vol. 87, No. 5, 2008, p. 1497-1503.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome

AU - Kallio, Petteri

AU - Kolehmainen, Marjukka

AU - Laaksonen, David E.

AU - Pulkkinen, Leena

AU - Atalay, Mustafa

AU - Mykkänen, Hannu

AU - Uusitupa, Matti

AU - Poutanen, Kaisa

AU - Niskanen, Leo

PY - 2008

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N2 - BACKGROUND: Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus. OBJECTIVE: We hypothesized that dietary carbohydrates characterized by different postprandial insulin responses may differentially modify cytokine concentrations in plasma and gene expression in subcutaneous adipose tissue. DESIGN: Individuals (n = 47) with the metabolic syndrome were randomly assigned to a 12-wk diet with oat and wheat bread and potato (high postprandial insulin response) or rye bread and pasta (low postprandial insulin response). Postprandial glucose and insulin responses to the oat and wheat bread meal and to the rye bread meal were determined in 19 individuals before intervention. RESULTS: During the 12-wk diet, the change in the gene expression of interleukin (IL)-10 receptor alpha and tumor necrosis factor-alpha in subcutaneous adipose tissue differed between the groups (P = 0.002 and P = 0.083, respectively). Moreover, the change in fasting plasma concentrations of IL-1beta and IL-6 differed between the groups (P = 0.020 and P = 0.055, respectively). In the postprandial challenge, the insulin response to the rye bread meal was lower than that to the oat and wheat bread meal (P < 0.001), whereas there were no differences in the mean blood glucose response. In contrast, plasma glucose concentrations decreased more below fasting concentrations 2.5-3 h after the oat and wheat bread meal than after the rye bread meal. A late postprandial rebound of free fatty acids was detected after the oat and wheat bread meal (P = 0.048). CONCLUSIONS: Long-term intake of cereal foods with differing postprandial insulin responses may be a factor that modulates the inflammatory status in individuals with the metabolic syndrome.

AB - BACKGROUND: Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus. OBJECTIVE: We hypothesized that dietary carbohydrates characterized by different postprandial insulin responses may differentially modify cytokine concentrations in plasma and gene expression in subcutaneous adipose tissue. DESIGN: Individuals (n = 47) with the metabolic syndrome were randomly assigned to a 12-wk diet with oat and wheat bread and potato (high postprandial insulin response) or rye bread and pasta (low postprandial insulin response). Postprandial glucose and insulin responses to the oat and wheat bread meal and to the rye bread meal were determined in 19 individuals before intervention. RESULTS: During the 12-wk diet, the change in the gene expression of interleukin (IL)-10 receptor alpha and tumor necrosis factor-alpha in subcutaneous adipose tissue differed between the groups (P = 0.002 and P = 0.083, respectively). Moreover, the change in fasting plasma concentrations of IL-1beta and IL-6 differed between the groups (P = 0.020 and P = 0.055, respectively). In the postprandial challenge, the insulin response to the rye bread meal was lower than that to the oat and wheat bread meal (P < 0.001), whereas there were no differences in the mean blood glucose response. In contrast, plasma glucose concentrations decreased more below fasting concentrations 2.5-3 h after the oat and wheat bread meal than after the rye bread meal. A late postprandial rebound of free fatty acids was detected after the oat and wheat bread meal (P = 0.048). CONCLUSIONS: Long-term intake of cereal foods with differing postprandial insulin responses may be a factor that modulates the inflammatory status in individuals with the metabolic syndrome.

KW - Gene-nutrient interactions

KW - adipose tissue

KW - inflammation

KW - cytokines

KW - postprandial response

U2 - 10.1093/ajcn/87.5.1497

DO - 10.1093/ajcn/87.5.1497

M3 - Article

VL - 87

SP - 1497

EP - 1503

JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

SN - 0002-9165

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ER -