Influence of blood pulsation on diagnostic volume in pulse oximetry and photoplethysmography measurements

Viktor Dremin, Evgeny Zherebtsov, Alexander Bykov, Alexey Popov, Alexander Doronin, Igor Meglinski (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

48 Citations (Scopus)


Recent advances in the development of ultra-compact semiconductor lasers and technology of printed flexible hybrid electronics have opened broad perspectives for the design of new pulse oximetry and photoplethysmography devices. Conceptual design of optical diagnostic devices requires careful selection of various technical parameters, including spectral range; polarization and intensity of incident light; actual size, geometry, and sensitivity of the detector; and mutual position of the source and detector on the surface of skin. In the current study utilizing a unified Monte Carlo computational tool, we explore the variations in diagnostic volume due to arterial blood pulsation for typical transmitted and back-scattered probing configurations in a human finger. The results of computational studies show that the variations in diagnostic volumes due to arterial pulse wave are notably (up to 45%) different in visible and near-infrared spectral ranges in both transmitted and back-scattered probing geometries. While these variations are acceptable for relative measurements in pulse oximetry and/or photoplethysmography, for absolute measurements, an alignment normalization of diagnostic volume is required and can be done by a computational approach utilized in the framework of the current study.

Original languageEnglish
Pages (from-to)9398-9405
Number of pages8
JournalApplied Optics
Issue number34
Publication statusPublished - 1 Dec 2019
MoE publication typeA1 Journal article-refereed


  • Arteries/physiology
  • Heart Rate/physiology
  • Humans
  • Monte Carlo Method
  • Oximetry/methods
  • Oxygen/blood
  • Photoplethysmography/methods
  • Pulsatile Flow/physiology


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