Abstract
Recent advances in the development of ultra-compact semiconductor lasers and technology of printed flexible hybrid electronics have opened broad perspectives for the design of new pulse oximetry and photoplethysmography devices. Conceptual design of optical diagnostic devices requires careful selection of various technical parameters, including spectral range; polarization and intensity of incident light; actual size, geometry, and sensitivity of the detector; and mutual position of the source and detector on the surface of skin. In the current study utilizing a unified Monte Carlo computational tool, we explore the variations in diagnostic volume due to arterial blood pulsation for typical transmitted and back-scattered probing configurations in a human finger. The results of computational studies show that the variations in diagnostic volumes due to arterial pulse wave are notably (up to 45%) different in visible and near-infrared spectral ranges in both transmitted and back-scattered probing geometries. While these variations are acceptable for relative measurements in pulse oximetry and/or photoplethysmography, for absolute measurements, an alignment normalization of diagnostic volume is required and can be done by a computational approach utilized in the framework of the current study.
Original language | English |
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Pages (from-to) | 9398-9405 |
Journal | Applied Optics |
Volume | 58 |
Issue number | 34 |
DOIs | |
Publication status | Published - 1 Dec 2019 |
MoE publication type | A1 Journal article-refereed |
Funding
Funding. Academy of Finland (290596, 314369, 318281); Russian Science Foundation (19-79-00082); Russian Foundation for Basic Research (18-02-00669); MEPhI Academic Excellence Project (02.a03.21.0005); National Research Tomsk State University Academic D.I. Mendeleev Fund Program; Grant of the President of the Russian Federation for state support of young Russian scientists (MK-3400.2018.8); INFOTECH Oulu; Victoria University of Wellington (220732); Engineering and Physical Sciences Research Council, (EP/R024898/1).
Keywords
- Arteries/physiology
- Heart Rate/physiology
- Humans
- Monte Carlo Method
- Oximetry/methods
- Oxygen/blood
- Photoplethysmography/methods
- Pulsatile Flow/physiology