@article{7544cf3041074c7593b7f9fb8d47d4f5,
title = "Influence of blood pulsation on diagnostic volume in pulse oximetry and photoplethysmography measurements",
abstract = "Recent advances in the development of ultra-compact semiconductor lasers and technology of printed flexible hybrid electronics have opened broad perspectives for the design of new pulse oximetry and photoplethysmography devices. Conceptual design of optical diagnostic devices requires careful selection of various technical parameters, including spectral range; polarization and intensity of incident light; actual size, geometry, and sensitivity of the detector; and mutual position of the source and detector on the surface of skin. In the current study utilizing a unified Monte Carlo computational tool, we explore the variations in diagnostic volume due to arterial blood pulsation for typical transmitted and back-scattered probing configurations in a human finger. The results of computational studies show that the variations in diagnostic volumes due to arterial pulse wave are notably (up to 45%) different in visible and near-infrared spectral ranges in both transmitted and back-scattered probing geometries. While these variations are acceptable for relative measurements in pulse oximetry and/or photoplethysmography, for absolute measurements, an alignment normalization of diagnostic volume is required and can be done by a computational approach utilized in the framework of the current study.",
keywords = "Arteries/physiology, Heart Rate/physiology, Humans, Monte Carlo Method, Oximetry/methods, Oxygen/blood, Photoplethysmography/methods, Pulsatile Flow/physiology",
author = "Viktor Dremin and Evgeny Zherebtsov and Alexander Bykov and Alexey Popov and Alexander Doronin and Igor Meglinski",
note = "Funding Information: Academy of Finland (290596, 314369, 318281); Russian Science Foundation (19-79-00082); Russian Foundation for Basic Research (18-02-00669); MEPhI Academic Excellence Project (02.a03.21.0005); National Research Tomsk State University Academic D.I. Mendeleev Fund Program; Grant of the President of the Russian Federation for state support of young Russian scientists (MK-3400.2018.8); INFOTECH Oulu; Victoria University of Wellington (220732); Engineering and Physical Sciences ResearchCouncil,(EP/R024898/1). The authors acknowledge the support of the Academy of Finland (grants 290596, 314369 and 318281). This study was also supported by the Russian Science Foundation under project No.19-79-00082 (development of a Monte Carlo model), Russian Foundation for Basic Research under project No.18-02-00669 (processing of simulation data), and grant of the President of the Russian Federation for state support of young Russian scientists (No. MK-3400.2018.8). The authors also acknowledge partial support from INFOTECH Oulu, Victoria University of Wellington (OCL grant: 220732), MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), and National Research Tomsk State University Academic D.I. Mendeleev Fund Program. This project has also received partial funding from the Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/R024898/1). The authors are very grateful to Dr. Matti Huiku (General Electrics: Healthcare, Finland) for the constructive comments and critical remarks at the initial stage in the framework of the current study. Funding Information: Acknowledgment. The authors acknowledge the support of the Academy of Finland (grants 290596, 314369 and 318281). This study was also supported by the Russian Science Foundation under project No.19-79-00082 (development of a Monte Carlo model), Russian Foundation for Basic Research under project No.18-02-00669 (processing of simulation data), and grant of the President of the Russian Federation for state support of young Russian scientists (No. MK-3400.2018.8). The authors also acknowledge partial support from INFOTECH Oulu, Victoria University of Wellington (OCL grant: 220732), MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), and National Research Tomsk State University Academic D.I. Mendeleev Fund Program. This project has also received partial funding from the Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/R024898/1). The authors are very grateful to Dr. Matti Huiku (General Electrics: Healthcare, Finland) for the constructive comments and critical remarks at the initial stage in the framework of the current study. Funding Information: Funding. Academy of Finland (290596, 314369, 318281); Russian Science Foundation (19-79-00082); Russian Foundation for Basic Research (18-02-00669); MEPhI Academic Excellence Project (02.a03.21.0005); National Research Tomsk State University Academic D.I. Mendeleev Fund Program; Grant of the President of the Russian Federation for state support of young Russian scientists (MK-3400.2018.8); INFOTECH Oulu; Victoria University of Wellington (220732); Engineering and Physical Sciences Research Council, (EP/R024898/1). Publisher Copyright: {\textcopyright} 2019 Optical Society of America. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2019",
month = dec,
day = "1",
doi = "10.1364/AO.58.009398",
language = "English",
volume = "58",
pages = "9398--9405",
journal = "Applied Optics",
issn = "1559-128X",
publisher = "Optical Society of America OSA",
number = "34",
}