Influence of diet and other factors on the levels of organochlorine compounds in human adipose tissue in Finland

Helena Mussalo-Rauhamaa, Heikki Pyysalo, Raija Moilanen

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Abstract

One hundred and five human adipose tissue samples were recovered during surgical operations or postmortem examinations of patients experiencing death due to traumatic injury. The sample donors were between the ages of 2 mo and 91 yr. Samples were analyzed by GLC‐MS techniques for polychlorobiophenyl (PCB) and dichlorodiphenyl trichloroethane (DDT) compounds, chlordanes, hexachlorobenzene, and chlorinated phenols. Special attention was paid to the concentration of heptachlor epoxide, a metabolite of heptachlor, commonly used as an insecticide in the Finnish plywood industry. The mean concentrations of PCB, DTTs, HCB, and chlordanes were 0.26, 0.33, 0.02, and 0.007 mg/kg fresh weight, respectively, while the mean concentration of heptachlor epoxide was 2.3 μg/kg. The geometric means were 0.20, 0.28, 0.018, 0.0055, and 0.002 mg/kg, respectively.

The concentrations of PCB and DDT compounds in Finnish human adipose tissue has rapidly decreased during the last 10 yr. The average concentrations were higher in south Finland than those in north Finland, and the results clearly indicate the prominent influence of fish meals and the age of sample donors on the pollutant concentrations in adipose tissue. The results were further analyzed and discussed with respect to sex, smoking habits, and number of childbirths of the sample donors.

Original languageEnglish
Pages (from-to)689 - 704
Number of pages16
JournalJournal of Toxicology and Environmental Health
Volume13
Issue number4-6
DOIs
Publication statusPublished - 1984
MoE publication typeNot Eligible

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Chlorinated Hydrocarbons
Heptachlor Epoxide
Finland
Nutrition
Chlordan
Trichloroethanes
Hexachlorobenzene
Adipose Tissue
Tissue Donors
Tissue
Diet
Heptachlor
Plywood
Insecticides
Phenols
Metabolites
Fish
Habits
Meals
Autopsy

Cite this

Mussalo-Rauhamaa, Helena ; Pyysalo, Heikki ; Moilanen, Raija. / Influence of diet and other factors on the levels of organochlorine compounds in human adipose tissue in Finland. In: Journal of Toxicology and Environmental Health. 1984 ; Vol. 13, No. 4-6. pp. 689 - 704.
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abstract = "One hundred and five human adipose tissue samples were recovered during surgical operations or postmortem examinations of patients experiencing death due to traumatic injury. The sample donors were between the ages of 2 mo and 91 yr. Samples were analyzed by GLC‐MS techniques for polychlorobiophenyl (PCB) and dichlorodiphenyl trichloroethane (DDT) compounds, chlordanes, hexachlorobenzene, and chlorinated phenols. Special attention was paid to the concentration of heptachlor epoxide, a metabolite of heptachlor, commonly used as an insecticide in the Finnish plywood industry. The mean concentrations of PCB, DTTs, HCB, and chlordanes were 0.26, 0.33, 0.02, and 0.007 mg/kg fresh weight, respectively, while the mean concentration of heptachlor epoxide was 2.3 μg/kg. The geometric means were 0.20, 0.28, 0.018, 0.0055, and 0.002 mg/kg, respectively. The concentrations of PCB and DDT compounds in Finnish human adipose tissue has rapidly decreased during the last 10 yr. The average concentrations were higher in south Finland than those in north Finland, and the results clearly indicate the prominent influence of fish meals and the age of sample donors on the pollutant concentrations in adipose tissue. The results were further analyzed and discussed with respect to sex, smoking habits, and number of childbirths of the sample donors.",
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Influence of diet and other factors on the levels of organochlorine compounds in human adipose tissue in Finland. / Mussalo-Rauhamaa, Helena; Pyysalo, Heikki; Moilanen, Raija.

In: Journal of Toxicology and Environmental Health, Vol. 13, No. 4-6, 1984, p. 689 - 704.

Research output: Contribution to journalArticleScientificpeer-review

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N2 - One hundred and five human adipose tissue samples were recovered during surgical operations or postmortem examinations of patients experiencing death due to traumatic injury. The sample donors were between the ages of 2 mo and 91 yr. Samples were analyzed by GLC‐MS techniques for polychlorobiophenyl (PCB) and dichlorodiphenyl trichloroethane (DDT) compounds, chlordanes, hexachlorobenzene, and chlorinated phenols. Special attention was paid to the concentration of heptachlor epoxide, a metabolite of heptachlor, commonly used as an insecticide in the Finnish plywood industry. The mean concentrations of PCB, DTTs, HCB, and chlordanes were 0.26, 0.33, 0.02, and 0.007 mg/kg fresh weight, respectively, while the mean concentration of heptachlor epoxide was 2.3 μg/kg. The geometric means were 0.20, 0.28, 0.018, 0.0055, and 0.002 mg/kg, respectively. The concentrations of PCB and DDT compounds in Finnish human adipose tissue has rapidly decreased during the last 10 yr. The average concentrations were higher in south Finland than those in north Finland, and the results clearly indicate the prominent influence of fish meals and the age of sample donors on the pollutant concentrations in adipose tissue. The results were further analyzed and discussed with respect to sex, smoking habits, and number of childbirths of the sample donors.

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