Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts

Eija Parmes (Corresponding Author), Giancarlo Pesce (Corresponding Author), Clive Sabel, Sandra Baldacci, Roberto Bono, Sonia Brescianini, Cristina D'Ippolito, Wojciech Hanke, Milena Horvat, Hilkka Liedes, Sara Maio, Pierpaolo Marchetti, Alessandro Marcon, Emmanuela Medda, Matthieu Molinier, Silvia Panunzi, Juha Pärkkä, Kinga Polanska, Julie Prud'homme, Paolo RicciJanja Snoj Tratnik, Giulia Squillacioti, Maria Antonietta Stazi, Cara Maesano, Isabella Annesi-Maesano

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Introduction
Recent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases.
Methods
Data from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses.
Results
In the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%–13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis.
Conclusion
Our results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space, and also the use of green space, in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.

Original languageEnglish
JournalEnvironmental Research
DOIs
Publication statusE-pub ahead of print - 22 Nov 2019
MoE publication typeA1 Journal article-refereed

Fingerprint

Pulmonary diseases
asthma
Respiratory Sounds
land cover
Asthma
respiratory disease
Eczema
Health
Allergies
coniferous forest
Logistic Models
Logistics
Buffers
general health
Education
allergy
Meta-Analysis
Hypersensitivity
forest cover
smoking

Keywords

  • land cover
  • green space
  • forests
  • allergy
  • asthma

Cite this

Parmes, Eija ; Pesce, Giancarlo ; Sabel, Clive ; Baldacci, Sandra ; Bono, Roberto ; Brescianini, Sonia ; D'Ippolito, Cristina ; Hanke, Wojciech ; Horvat, Milena ; Liedes, Hilkka ; Maio, Sara ; Marchetti, Pierpaolo ; Marcon, Alessandro ; Medda, Emmanuela ; Molinier, Matthieu ; Panunzi, Silvia ; Pärkkä, Juha ; Polanska, Kinga ; Prud'homme, Julie ; Ricci, Paolo ; Snoj Tratnik, Janja ; Squillacioti, Giulia ; Stazi, Maria Antonietta ; Maesano, Cara ; Annesi-Maesano, Isabella. / Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts. In: Environmental Research. 2019.
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title = "Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts",
abstract = "IntroductionRecent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases.MethodsData from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses.ResultsIn the pooled analyses, a 10{\%} increase in green space coverage was significantly associated with a 5.9{\%}–13.0{\%} increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis.ConclusionOur results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space, and also the use of green space, in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.",
keywords = "land cover, green space, forests, allergy, asthma",
author = "Eija Parmes and Giancarlo Pesce and Clive Sabel and Sandra Baldacci and Roberto Bono and Sonia Brescianini and Cristina D'Ippolito and Wojciech Hanke and Milena Horvat and Hilkka Liedes and Sara Maio and Pierpaolo Marchetti and Alessandro Marcon and Emmanuela Medda and Matthieu Molinier and Silvia Panunzi and Juha P{\"a}rkk{\"a} and Kinga Polanska and Julie Prud'homme and Paolo Ricci and {Snoj Tratnik}, Janja and Giulia Squillacioti and Stazi, {Maria Antonietta} and Cara Maesano and Isabella Annesi-Maesano",
year = "2019",
month = "11",
day = "22",
doi = "j.envres.2019.108953",
language = "English",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Elsevier",

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Parmes, E, Pesce, G, Sabel, C, Baldacci, S, Bono, R, Brescianini, S, D'Ippolito, C, Hanke, W, Horvat, M, Liedes, H, Maio, S, Marchetti, P, Marcon, A, Medda, E, Molinier, M, Panunzi, S, Pärkkä, J, Polanska, K, Prud'homme, J, Ricci, P, Snoj Tratnik, J, Squillacioti, G, Stazi, MA, Maesano, C & Annesi-Maesano, I 2019, 'Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts', Environmental Research. https://doi.org/j.envres.2019.108953

Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts. / Parmes, Eija (Corresponding Author); Pesce, Giancarlo (Corresponding Author); Sabel, Clive; Baldacci, Sandra; Bono, Roberto; Brescianini, Sonia; D'Ippolito, Cristina; Hanke, Wojciech; Horvat, Milena; Liedes, Hilkka; Maio, Sara ; Marchetti, Pierpaolo; Marcon, Alessandro; Medda, Emmanuela; Molinier, Matthieu; Panunzi, Silvia; Pärkkä, Juha; Polanska, Kinga; Prud'homme, Julie; Ricci, Paolo; Snoj Tratnik, Janja; Squillacioti, Giulia; Stazi, Maria Antonietta; Maesano, Cara; Annesi-Maesano, Isabella.

In: Environmental Research, 22.11.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts

AU - Parmes, Eija

AU - Pesce, Giancarlo

AU - Sabel, Clive

AU - Baldacci, Sandra

AU - Bono, Roberto

AU - Brescianini, Sonia

AU - D'Ippolito, Cristina

AU - Hanke, Wojciech

AU - Horvat, Milena

AU - Liedes, Hilkka

AU - Maio, Sara

AU - Marchetti, Pierpaolo

AU - Marcon, Alessandro

AU - Medda, Emmanuela

AU - Molinier, Matthieu

AU - Panunzi, Silvia

AU - Pärkkä, Juha

AU - Polanska, Kinga

AU - Prud'homme, Julie

AU - Ricci, Paolo

AU - Snoj Tratnik, Janja

AU - Squillacioti, Giulia

AU - Stazi, Maria Antonietta

AU - Maesano, Cara

AU - Annesi-Maesano, Isabella

PY - 2019/11/22

Y1 - 2019/11/22

N2 - IntroductionRecent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases.MethodsData from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses.ResultsIn the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%–13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis.ConclusionOur results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space, and also the use of green space, in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.

AB - IntroductionRecent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases.MethodsData from 8063 children, aged 3–14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses.ResultsIn the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%–13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis.ConclusionOur results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space, and also the use of green space, in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.

KW - land cover

KW - green space

KW - forests

KW - allergy

KW - asthma

U2 - j.envres.2019.108953

DO - j.envres.2019.108953

M3 - Article

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -