Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis

Tao He (Corresponding Author), Saija Haapa-Paananen, V.O. Kaminskyy, Pekka Kohonen, Vidal Fey, B. Zhivotovsky, Olli Kallioniemi, Merja Perälä

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science