Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27

Ken-Ichi Harada (Corresponding Author), Mette Suomalainen, Hideaki Uchida, Hiroaki Masui, Kuniyo Ohmura, Jari Kiviranta, Marja-Leena Niku-Paavola, Takaya Ikemoto

Research output: Contribution to journalArticleScientificpeer-review

29 Citations (Scopus)

Abstract

It was found that Oscillatoria agardhii strain 27 produced compounds toxic against mosquito larvae (Aedes albopictus), therefore, these compounds were extracted and separated for insecticide development. Structural characterization of the toxic fraction by 1H‐NMR and GC‐MS showed that these compounds are not the neurotoxins or hepatotoxins conventionally produced by Oscillatoria, but it contained a mixture of unsaturated fatty acids, oleic, linoleic, and γ‐linolenic acids, as well as saturated fatty acids, myristic, palmitic, and stearic acids. In a bioassay developed for these hydrophobic compounds using mosquito larvae, authentic unsaturated fatty acids were shown to be toxic, whereas saturated ones were not active. The results suggested that it might be possible to use unsaturated fatty acids as environmentally safe and effective insecticides without the side effects of the chemically synthesized insecticides.

Original languageEnglish
Pages (from-to)114 - 119
Number of pages6
JournalEnvironmental Toxicology
Volume15
Issue number2
DOIs
Publication statusPublished - 2000
MoE publication typeA1 Journal article-refereed

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Oscillatoria
Poisons
Insecticides
Culicidae
mosquito
Unsaturated Fatty Acids
Larva
fatty acid
larva
insecticide
Linolenic Acids
Stearic Acids
Oleic Acids
Linoleic Acids
Bioassay
Aedes
Neurotoxins
Biological Assay
Gas Chromatography-Mass Spectrometry
acid

Cite this

Harada, K-I., Suomalainen, M., Uchida, H., Masui, H., Ohmura, K., Kiviranta, J., ... Ikemoto, T. (2000). Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27. Environmental Toxicology, 15(2), 114 - 119. https://doi.org/10.1002/(SICI)1522-7278(2000)15:2<114::AID-TOX7>3.0.CO;2-P
Harada, Ken-Ichi ; Suomalainen, Mette ; Uchida, Hideaki ; Masui, Hiroaki ; Ohmura, Kuniyo ; Kiviranta, Jari ; Niku-Paavola, Marja-Leena ; Ikemoto, Takaya. / Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27. In: Environmental Toxicology. 2000 ; Vol. 15, No. 2. pp. 114 - 119.
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abstract = "It was found that Oscillatoria agardhii strain 27 produced compounds toxic against mosquito larvae (Aedes albopictus), therefore, these compounds were extracted and separated for insecticide development. Structural characterization of the toxic fraction by 1H‐NMR and GC‐MS showed that these compounds are not the neurotoxins or hepatotoxins conventionally produced by Oscillatoria, but it contained a mixture of unsaturated fatty acids, oleic, linoleic, and γ‐linolenic acids, as well as saturated fatty acids, myristic, palmitic, and stearic acids. In a bioassay developed for these hydrophobic compounds using mosquito larvae, authentic unsaturated fatty acids were shown to be toxic, whereas saturated ones were not active. The results suggested that it might be possible to use unsaturated fatty acids as environmentally safe and effective insecticides without the side effects of the chemically synthesized insecticides.",
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Harada, K-I, Suomalainen, M, Uchida, H, Masui, H, Ohmura, K, Kiviranta, J, Niku-Paavola, M-L & Ikemoto, T 2000, 'Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27', Environmental Toxicology, vol. 15, no. 2, pp. 114 - 119. https://doi.org/10.1002/(SICI)1522-7278(2000)15:2<114::AID-TOX7>3.0.CO;2-P

Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27. / Harada, Ken-Ichi (Corresponding Author); Suomalainen, Mette; Uchida, Hideaki; Masui, Hiroaki; Ohmura, Kuniyo; Kiviranta, Jari; Niku-Paavola, Marja-Leena; Ikemoto, Takaya.

In: Environmental Toxicology, Vol. 15, No. 2, 2000, p. 114 - 119.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Insecticidal compounds against mosquito larvae from Oscillatoria agardhii strain 27

AU - Harada, Ken-Ichi

AU - Suomalainen, Mette

AU - Uchida, Hideaki

AU - Masui, Hiroaki

AU - Ohmura, Kuniyo

AU - Kiviranta, Jari

AU - Niku-Paavola, Marja-Leena

AU - Ikemoto, Takaya

PY - 2000

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AB - It was found that Oscillatoria agardhii strain 27 produced compounds toxic against mosquito larvae (Aedes albopictus), therefore, these compounds were extracted and separated for insecticide development. Structural characterization of the toxic fraction by 1H‐NMR and GC‐MS showed that these compounds are not the neurotoxins or hepatotoxins conventionally produced by Oscillatoria, but it contained a mixture of unsaturated fatty acids, oleic, linoleic, and γ‐linolenic acids, as well as saturated fatty acids, myristic, palmitic, and stearic acids. In a bioassay developed for these hydrophobic compounds using mosquito larvae, authentic unsaturated fatty acids were shown to be toxic, whereas saturated ones were not active. The results suggested that it might be possible to use unsaturated fatty acids as environmentally safe and effective insecticides without the side effects of the chemically synthesized insecticides.

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