Integrated breast cancer genomics

Henrik Edgren, Olli Kallioniemi (Corresponding Author)

Research output: Contribution to journalReview Articlepeer-review

4 Citations (Scopus)

Abstract

Predicting survival and therapy responses of breast cancer patients is a significant challenge. Two studies in this issue of Cancer Cell present a novel integrated analysis of genomic and transcriptomic profiles of 145 primary breast cancers and 51 established cell lines. Data from clinical tumors highlighted mechanisms of disease and facilitated identification of potential therapeutic targets and prognostic biomarkers. An extensive well-characterized cancer cell line resource opens up opportunities to explore the determinants of cellular responses to existing and emerging therapies. Taken together, these studies illustrate how integrated molecular profiling may one day significantly impact diagnosis and therapeutic choice in human breast cancer.
Original languageEnglish
Pages (from-to)453-454
JournalCancer Cell
Volume10
Issue number6
DOIs
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal

Keywords

  • cell lines
  • breast cancer
  • breast cancer risk
  • cellular response
  • therapeutic response
  • therapies

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