Integrated chip for liquid chromatography separation and atmospheric pressure ionization for mass spectrometry

Ville Saarela, Markus Haapala, Jaroslav Pól, Kai Kolari, Tapio Kotiaho, Risto Kostiainen, Sami Franssila

Research output: Contribution to conferenceConference articleScientificpeer-review

Abstract

We present a novel microfluidic chip that combines liquid chromatography (LC) column and heated nebulizer on a single chip. The heated nebulizer enables ionization using either atmospheric pressure chemical ionization (APCI) or atmospheric pressure photoionization (APPI) prior to detection by mass spectrometry (MS). The integrated chip is based on our previously presented separate LC and heated nebulizer chips.
Original languageEnglish
Publication statusPublished - 2009
MoE publication typeNot Eligible
Event35th International Conference on Micro & Nano Engineering, MNE 2009 - Ghent, Belgium
Duration: 28 Sep 20091 Oct 2009

Conference

Conference35th International Conference on Micro & Nano Engineering, MNE 2009
CountryBelgium
CityGhent
Period28/09/091/10/09

Keywords

  • silicon
  • microfluidics
  • liquid chromatography
  • mass spectrometry

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    Saarela, V., Haapala, M., Pól, J., Kolari, K., Kotiaho, T., Kostiainen, R., & Franssila, S. (2009). Integrated chip for liquid chromatography separation and atmospheric pressure ionization for mass spectrometry. Paper presented at 35th International Conference on Micro & Nano Engineering, MNE 2009, Ghent, Belgium.