Abstract
| Original language | English |
|---|---|
| Title of host publication | Bio-MEMS and Medical Microdevices III |
| Editors | Ioanna Giouroudi, Ioanna Giouroudi, Manuel Delgado-Restituto, Sander van den Driesche |
| Volume | 10247 |
| ISBN (Electronic) | 9781510609952 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
| MoE publication type | A4 Article in a conference publication |
| Event | Bio-MEMS and Medical Microdevices III Conference 2017 - Barcelona, Spain Duration: 9 May 2017 → 10 May 2017 |
Publication series
| Name | Proceedings of SPIE |
|---|---|
| Publisher | SPIE |
| Volume | 10247 |
| ISSN (Print) | 0277-786X |
Conference
| Conference | Bio-MEMS and Medical Microdevices III Conference 2017 |
|---|---|
| Country | Spain |
| City | Barcelona |
| Period | 9/05/17 → 10/05/17 |
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Keywords
- capacitive pressure sensor
- catheter integration
- chip bumping & coining
- die thinning
- flexible circuit
- flip chip interconnect
- fractional Flow Reserve (FFR)
- solder laser jetting
- Fractional Flow Reserve (FFR)
Cite this
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Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements. / Stam, Frank; Kuisma, Heikki; Gao, Feng; Saarilahti, Jaakko; Gomes Martins, David; Kärkkäinen, Anu; Marrinan, Brendan; Pintal, Sebastian.
Bio-MEMS and Medical Microdevices III. ed. / Ioanna Giouroudi; Ioanna Giouroudi; Manuel Delgado-Restituto; Sander van den Driesche. Vol. 10247 2017. 1024703 (Proceedings of SPIE, Vol. 10247).Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review
TY - GEN
T1 - Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements
AU - Stam, Frank
AU - Kuisma, Heikki
AU - Gao, Feng
AU - Saarilahti, Jaakko
AU - Gomes Martins, David
AU - Kärkkäinen, Anu
AU - Marrinan, Brendan
AU - Pintal, Sebastian
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The deadliest disease in the world is coronary artery disease (CAD), which is related to a narrowing (stenosis) of blood vessels due to fatty deposits, plaque, on the arterial walls. The level of stenosis in the coronary arteries can be assessed by Fractional Flow Reserve (FFR) measurements. This involves determining the ratio between the maximum achievable blood flow in a diseased coronary artery and the theoretical maximum flow in a normal coronary artery. The blood flow is represented by a pressure drop, thus a pressure wire or pressure sensor integrated in a catheter can be used to calculate the ratio between the coronary pressure distal to the stenosis and the normal coronary pressure. A 2 Fr (0.67mm) outer diameter catheter was used, which required a high level of microelectronics miniaturisation to fit a pressure sensing system into the outer wall. The catheter has an eccentric guidewire lumen with a diameter of 0.43mm, which implies that the thickest catheter wall section provides less than 210 microns height for flex assembly integration consisting of two dies, a capacitive MEMS pressure sensor and an ASIC. In order to achieve this a very thin circuit flex was used, and the two chips were thinned down to 75 microns and flip chip mounted face down on the flex. Many challenges were involved in obtaining a flex layout that could wrap into a small tube without getting the dies damaged, while still maintaining enough flexibility for the catheter to navigate the arterial system.
AB - The deadliest disease in the world is coronary artery disease (CAD), which is related to a narrowing (stenosis) of blood vessels due to fatty deposits, plaque, on the arterial walls. The level of stenosis in the coronary arteries can be assessed by Fractional Flow Reserve (FFR) measurements. This involves determining the ratio between the maximum achievable blood flow in a diseased coronary artery and the theoretical maximum flow in a normal coronary artery. The blood flow is represented by a pressure drop, thus a pressure wire or pressure sensor integrated in a catheter can be used to calculate the ratio between the coronary pressure distal to the stenosis and the normal coronary pressure. A 2 Fr (0.67mm) outer diameter catheter was used, which required a high level of microelectronics miniaturisation to fit a pressure sensing system into the outer wall. The catheter has an eccentric guidewire lumen with a diameter of 0.43mm, which implies that the thickest catheter wall section provides less than 210 microns height for flex assembly integration consisting of two dies, a capacitive MEMS pressure sensor and an ASIC. In order to achieve this a very thin circuit flex was used, and the two chips were thinned down to 75 microns and flip chip mounted face down on the flex. Many challenges were involved in obtaining a flex layout that could wrap into a small tube without getting the dies damaged, while still maintaining enough flexibility for the catheter to navigate the arterial system.
KW - capacitive pressure sensor
KW - catheter integration
KW - chip bumping & coining
KW - die thinning
KW - flexible circuit
KW - flip chip interconnect
KW - fractional Flow Reserve (FFR)
KW - solder laser jetting
KW - Fractional Flow Reserve (FFR)
UR - http://www.scopus.com/inward/record.url?scp=85025682367&partnerID=8YFLogxK
U2 - 10.1117/12.2263779
DO - 10.1117/12.2263779
M3 - Conference article in proceedings
SN - 978-151060995-2
VL - 10247
T3 - Proceedings of SPIE
BT - Bio-MEMS and Medical Microdevices III
A2 - Giouroudi, Ioanna
A2 - Giouroudi, Ioanna
A2 - Delgado-Restituto, Manuel
A2 - van den Driesche, Sander
ER -