Integrin inactivators: Balancing cellular functions in vitro and in vivo

Daniel Bouward, Jeroen Pouwels, Nicola De Franceschi, Johanna Ivaska (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

128 Citations (Scopus)

Abstract

Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated by their activity switching such that intracellular proteins interacting with the integrin cytoplasmic domains increase or decrease integrin–ligand binding affinity. It is widely accepted that integrin activation by specific proteins is essential for cell adhesion and integrin linkage to the actin cytoskeleton. However, there is also increasing evidence that integrin-inactivating proteins are crucial for appropriate integrin function in vitro and in vivo and that the regulation of integrin–ligand interactions is a fine-tuned balancing act between inactivation and activation.
Original languageEnglish
Pages (from-to)430-442
JournalNature Reviews: Molecular Cell Biology
Volume14
Issue number7
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

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