Integrins and Mutant p53 on the Road to Metastasis

Galina Selivanova; Johanna Ivaska

doi:10.1016/j.cell.2009.12.016

Integrins and Mutant p53 on the Road to Metastasis

Galina Selivanova, Johanna Ivaska (Corresponding Author)

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

23 Citations (Scopus)

Abstract

Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin α5β1 and of epidermal growth factor receptor, promoting invasion and metastasis.

Original language	English
Pages (from-to)	1220-1222
Journal	Cell
Volume	139
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2009.12.016
Publication status	Published - 2009
MoE publication type	A1 Journal article-refereed

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2009.12.016

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title = "Integrins and Mutant p53 on the Road to Metastasis",

abstract = "Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin α5β1 and of epidermal growth factor receptor, promoting invasion and metastasis.",

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AU - Ivaska, Johanna

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AB - Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin α5β1 and of epidermal growth factor receptor, promoting invasion and metastasis.

U2 - 10.1016/j.cell.2009.12.016

DO - 10.1016/j.cell.2009.12.016

M3 - Article

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VL - 139

SP - 1220

EP - 1222

JO - Cell

JF - Cell

IS - 7

ER -

Integrins and Mutant p53 on the Road to Metastasis

Abstract

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